4-(2-fluorophenyl)-3-(2-hydroxyethyl)-2-(4-methyl-1-piperazinyl)quinoline

Base Information

Chemical Name:4-(2-fluorophenyl)-3-(2-hydroxyethyl)-2-(4-methyl-1-piperazinyl)quinoline
CAS No.:151110-30-4
Molecular Formula:C₂₂H₂₄FN₃O
Molecular Weight:365.45
Hs Code.:

Synonyms:4-(2-fluorophenyl)-3-(2-hydroxyethyl)-2-(4-methyl-1-piperazinyl)quinoline

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Chemical Property of 4-(2-fluorophenyl)-3-(2-hydroxyethyl)-2-(4-methyl-1-piperazinyl)quinoline

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Technology Process of 4-(2-fluorophenyl)-3-(2-hydroxyethyl)-2-(4-methyl-1-piperazinyl)quinoline

There total 7 articles about 4-(2-fluorophenyl)-3-(2-hydroxyethyl)-2-(4-methyl-1-piperazinyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 151080-41-0
ethyl 4-(2-fluorophenyl)-2-(4-methyl-1-piperazinyl)quinoline-3-acetate

: 151110-30-4
4-(2-fluorophenyl)-3-(2-hydroxyethyl)-2-(4-methyl-1-piperazinyl)quinoline

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at -20 - 0 ℃; for 0.5h;
DOI:10.3987/COM-92-6276

Reference yield:

: 109-01-3
1-methyl-piperazine

: 151110-30-4
4-(2-fluorophenyl)-3-(2-hydroxyethyl)-2-(4-methyl-1-piperazinyl)quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / 8 h / 125 - 130 °C

2: 94 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / -20 - 0 °C

With lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.3987/COM-92-6276

Reference yield:

: 1581-13-1
2-amino-2'-fluorobenzophenone

: 151110-30-4
4-(2-fluorophenyl)-3-(2-hydroxyethyl)-2-(4-methyl-1-piperazinyl)quinoline

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / CH₂Cl₂ / 3 h / Ambient temperature

2: t-BuOK / ethanol / 1.17 h / Heating

3: POCl₃ / Ambient temperature

4: 91 percent / POCl₃ / 2 h

5: 85 percent / 8 h / 125 - 130 °C

6: 94 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / -20 - 0 °C

With lithium aluminium tetrahydride; potassium tert-butylate; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.3987/COM-92-6276