Benzyl-[(1R,2S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-5-oxo-2-triphenylsilanyloxy-pentyl]-carbamic acid benzyl ester

Base Information

Chemical Name:Benzyl-[(1R,2S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-5-oxo-2-triphenylsilanyloxy-pentyl]-carbamic acid benzyl ester
CAS No.:199786-63-5
Molecular Formula:C₄₅H₅₃NO₆Si₂
Molecular Weight:760.09
Hs Code.:

Synonyms:Benzyl-[(1R,2S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-5-oxo-2-triphenylsilanyloxy-pentyl]-carbamic acid benzyl ester

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Chemical Property of Benzyl-[(1R,2S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-5-oxo-2-triphenylsilanyloxy-pentyl]-carbamic acid benzyl ester

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Technology Process of Benzyl-[(1R,2S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-5-oxo-2-triphenylsilanyloxy-pentyl]-carbamic acid benzyl ester

There total 12 articles about Benzyl-[(1R,2S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-5-oxo-2-triphenylsilanyloxy-pentyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 199786-67-9
Benzyl-[(1R,2S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-4,5-dihydroxy-2-triphenylsilanyloxy-pentyl]-carbamic acid benzyl ester

: 199786-63-5
Benzyl-[(1R,2S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-5-oxo-2-triphenylsilanyloxy-pentyl]-carbamic acid benzyl ester

Guidance literature:: With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium bromide; In water; ethyl acetate; toluene; at 0 ℃;
DOI:10.1016/S0040-4039(97)10166-6

Reference yield:

: 199786-65-7
N-benzyl-N-carbobenzyloxy-O-tert-butyldimethylsilyl-D-serinal

: 199786-63-5
Benzyl-[(1R,2S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-5-oxo-2-triphenylsilanyloxy-pentyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Zn; AlCl₃ / tetrahydrofuran / 0.5 h / 20 °C

2: 80 percent / CH₂Cl₂; pyridine / 20 h

3: 83 percent / n-methylmorpholine; OsO₄ / tetrahydrofuran; 2-methyl-propan-2-ol; H₂O / 6 h

4: NaBr; TEMPO; NaHCO₃ / NaOCl / toluene; ethyl acetate; H₂O / 0 °C

With 4-methyl-morpholine; 2,2,6,6-tetramethyl-piperidine-N-oxyl; osmium(VIII) oxide; aluminium trichloride; sodium hydrogencarbonate; sodium bromide; zinc; sodium hypochlorite; In tetrahydrofuran; pyridine; dichloromethane; water; ethyl acetate; toluene; tert-butyl alcohol;

Reference yield:

: 199786-64-6
Benzyl-[(1R,2S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-triphenylsilanyloxy-pent-4-enyl]-carbamic acid benzyl ester

: 199786-63-5
Benzyl-[(1R,2S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-5-oxo-2-triphenylsilanyloxy-pentyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / n-methylmorpholine; OsO₄ / tetrahydrofuran; 2-methyl-propan-2-ol; H₂O / 6 h

2: NaBr; TEMPO; NaHCO₃ / NaOCl / toluene; ethyl acetate; H₂O / 0 °C

With 4-methyl-morpholine; 2,2,6,6-tetramethyl-piperidine-N-oxyl; osmium(VIII) oxide; sodium hydrogencarbonate; sodium bromide; sodium hypochlorite; In tetrahydrofuran; water; ethyl acetate; toluene; tert-butyl alcohol;