2-[(4-chlorophenyl)ethynyl]phenyl methoxymethyl sulfide

Base Information

• Chemical Name: 2-[(4-chlorophenyl)ethynyl]phenyl methoxymethyl sulfide
• CAS No.: 1610038-66-8
• Molecular Formula: C₁₆H₁₃ClOS
• Molecular Weight: 288.798
• Mol file: 1610038-66-8.mol

Synonyms:2-[(4-chlorophenyl)ethynyl]phenyl methoxymethyl sulfide

Chemical Property of 2-[(4-chlorophenyl)ethynyl]phenyl methoxymethyl sulfide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-[(4-chlorophenyl)ethynyl]phenyl methoxymethyl sulfide

There total 2 articles about 2-[(4-chlorophenyl)ethynyl]phenyl methoxymethyl sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-iodophenyl methoxymethyl sulfide (909275-31-6) + 4-n-chlorophenylacetylene (873-73-4) → 2-[(4-chlorophenyl)ethynyl]phenyl methoxymethyl sulfide (1610038-66-8)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 20 ℃; for 2.5h; Inert atmosphere;

DOI:10.1039/c4ob00299g

Reference yield:

2-iodophenylamine (615-43-0) → 2-[(4-chlorophenyl)ethynyl]phenyl methoxymethyl sulfide (1610038-66-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrafluoroboric acid; isopentyl nitrite / ethanol; water / 0.33 h / 0 °C

1.2: 1.33 h / -40 - 0 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 2.5 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrafluoroboric acid; triethylamine; isopentyl nitrite; In ethanol; water; 2.1: |Sonogashira Cross-Coupling;

DOI:10.1039/c4ob00299g

Reference yield: 84.0%

carbon monoxide (201230-82-2) + 2-[(4-chlorophenyl)ethynyl]phenyl methoxymethyl sulfide (1610038-66-8) → bis[2-(4-chlorophenyl)benzo[b]thiophen-3-yl]methanone (937637-40-6)

Guidance literature:

With C₂₅H₂₂F₆N₂O₆Pd; p-benzoquinone; In methanol; at -30 - -10 ℃; for 72h;

DOI:10.1039/c4ob00299g

upstream raw materials:

2-iodophenylamine

2-iodophenyl methoxymethyl sulfide

4-n-chlorophenylacetylene

Downstream raw materials:

bis[2-(4-chlorophenyl)benzo[b]thiophen-3-yl]methanone

Refernces