(S)-ethyl 2-(4-((5-chloro-4-((1-(2-fluorophenyl)-2-hydroxyethyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)acetate

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Chemical Name:(S)-ethyl 2-(4-((5-chloro-4-((1-(2-fluorophenyl)-2-hydroxyethyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)acetate
CAS No.:1420892-71-2
Molecular Formula:C₁₉H₂₀ClFN₆O₃
Molecular Weight:434.858
Hs Code.:

Synonyms:(S)-ethyl 2-(4-((5-chloro-4-((1-(2-fluorophenyl)-2-hydroxyethyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)acetate

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Chemical Property of (S)-ethyl 2-(4-((5-chloro-4-((1-(2-fluorophenyl)-2-hydroxyethyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)acetate

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Technology Process of (S)-ethyl 2-(4-((5-chloro-4-((1-(2-fluorophenyl)-2-hydroxyethyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)acetate

There total 1 articles about (S)-ethyl 2-(4-((5-chloro-4-((1-(2-fluorophenyl)-2-hydroxyethyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1420892-70-1
(S)-2-((2,5-dichloropyrimidin-4-yl)amino)-2-(2-fluorophenyl)ethanol

: 1152841-53-6
ethyl 2-(4-amino-1H-pyrazol-1-yl)acetate

: 1420892-71-2
(S)-ethyl 2-(4-((5-chloro-4-((1-(2-fluorophenyl)-2-hydroxyethyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)acetate

Guidance literature:: (S)-2-((2,5-dichloropyrimidin-4-yl)amino)-2-(2-fluorophenyl)ethanol; ethyl 2-(4-amino-1H-pyrazol-1-yl)acetate; With hydrogenchloride; In 1,4-dioxane; ethanol; at 50 ℃; for 40h;

With sodium hydrogencarbonate; In 1,4-dioxane; ethanol; water; ethyl acetate;

Reference yield:

: 1420892-71-2
(S)-ethyl 2-(4-((5-chloro-4-((1-(2-fluorophenyl)-2-hydroxyethyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)acetate

: 1420891-21-9
C₁₇H₁₇ClFN₇O₂

Guidance literature:: With ammonia; In methanol; at 20 ℃; for 64h; Temperature; Time; Wavelength;

Reference yield:

: 1420892-71-2
(S)-ethyl 2-(4-((5-chloro-4-((1-(2-fluorophenyl)-2-hydroxyethyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)acetate

: (S)-2-(4-((5-chloro-4-(1-(2-fluorophenyl)-2-hydroxyethyl)amino)pyrimidin-2-yl)amino-1H-pyrazol-1-yl)acetamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia / methanol / 64 h / 20 °C

2: hydrogenchloride / isopropyl alcohol / 60 °C

With hydrogenchloride; ammonia; In methanol; isopropyl alcohol;