5-(5-((4-chlorophenyl)(methyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid

Base Information

Chemical Name:5-(5-((4-chlorophenyl)(methyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid
CAS No.:1245734-60-4
Molecular Formula:C₂₈H₂₁ClN₂O₅
Molecular Weight:500.938
Hs Code.:

Synonyms:5-(5-((4-chlorophenyl)(methyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid

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Chemical Property of 5-(5-((4-chlorophenyl)(methyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid

Chemical Property:

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Technology Process of 5-(5-((4-chlorophenyl)(methyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid

There total 12 articles about 5-(5-((4-chlorophenyl)(methyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₂₃ClN₂O₅

: 1245734-60-4
5-(5-((4-chlorophenyl)(methyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid

Guidance literature:: With sodium hydroxide; In water; at 60 ℃; for 0.5h;
DOI:10.1124/jpet.115.227157

Reference yield:

: 1244043-46-6
5-((4-chlorophenyl)(methyl)amino)pyridine-2-carbaldehyde

: 1245734-60-4
5-(5-((4-chlorophenyl)(methyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: isopropylmagnesium chloride / tetrahydrofuran; methanol / -80 °C

2: manganese(IV) oxide / 60 °C

3: sodium hydroxide / water / 0.5 h / 60 °C

With manganese(IV) oxide; isopropylmagnesium chloride; sodium hydroxide; In tetrahydrofuran; methanol; water; 1: |Grignard Reaction;
DOI:10.1124/jpet.115.227157

Reference yield:

: 31181-90-5
5-bromo-pyridine-2-carbaldehyde

: 1245734-60-4
5-(5-((4-chlorophenyl)(methyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / toluene / 12 h / 80 °C

2: isopropylmagnesium chloride / tetrahydrofuran; methanol / -80 °C

3: manganese(IV) oxide / 60 °C

4: sodium hydroxide / water / 0.5 h / 60 °C

With manganese(IV) oxide; isopropylmagnesium chloride; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium hydroxide; In tetrahydrofuran; methanol; water; toluene; 1: |Buchwald-Hartwig Coupling / 2: |Grignard Reaction;
DOI:10.1124/jpet.115.227157