methyl 4-(3-(3'-methoxy[1,1'-biphenyl]-2-yl)-3-oxoprop-1-yn-1-yl)benzoate

Base Information

Chemical Name:methyl 4-(3-(3'-methoxy[1,1'-biphenyl]-2-yl)-3-oxoprop-1-yn-1-yl)benzoate
CAS No.:1587718-70-4
Molecular Formula:C₂₄H₁₈O₄
Molecular Weight:370.405
Hs Code.:

Synonyms:methyl 4-(3-(3'-methoxy[1,1'-biphenyl]-2-yl)-3-oxoprop-1-yn-1-yl)benzoate

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Chemical Property of methyl 4-(3-(3'-methoxy[1,1'-biphenyl]-2-yl)-3-oxoprop-1-yn-1-yl)benzoate

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Technology Process of methyl 4-(3-(3'-methoxy[1,1'-biphenyl]-2-yl)-3-oxoprop-1-yn-1-yl)benzoate

There total 3 articles about methyl 4-(3-(3'-methoxy[1,1'-biphenyl]-2-yl)-3-oxoprop-1-yn-1-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1394284-79-7
methyl 4-(3-(2-bromophenyl)-3-oxoprop-1-yn-1-yl)benzoate

: 10365-98-7,1107579-37-2
3-methoxyphenylboronic acid

: 1587718-70-4
methyl 4-(3-(3'-methoxy[1,1'-biphenyl]-2-yl)-3-oxoprop-1-yn-1-yl)benzoate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In tetrahydrofuran; at 120 ℃; for 2h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/jo5001803

Reference yield:

: 7154-66-7
2-bromobenzoic acid chloride

: 1587718-70-4
methyl 4-(3-(3'-methoxy[1,1'-biphenyl]-2-yl)-3-oxoprop-1-yn-1-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / tetrahydrofuran / 2 h / 120 °C / Inert atmosphere; Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; triethylamine; In tetrahydrofuran; 1: |Sonogashira Cross-Coupling / 2: |Suzuki-Miyaura Coupling;
DOI:10.1021/jo5001803

Reference yield:

: 3034-86-4
4-ethynylbenzoic acid methyl ester

: 1587718-70-4
methyl 4-(3-(3'-methoxy[1,1'-biphenyl]-2-yl)-3-oxoprop-1-yn-1-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / tetrahydrofuran / 2 h / 120 °C / Inert atmosphere; Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; triethylamine; In tetrahydrofuran; 1: |Sonogashira Cross-Coupling / 2: |Suzuki-Miyaura Coupling;
DOI:10.1021/jo5001803