tert-butyl 4-[(hydroxyamino)carbonyl]-4-{[(4-phenoxyphenyl)sulfonyl]methyl}piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[(hydroxyamino)carbonyl]-4-{[(4-phenoxyphenyl)sulfonyl]methyl}piperidine-1-carboxylate
CAS No.:213013-88-8
Molecular Formula:C₂₄H₃₀N₂O₇S
Molecular Weight:490.577
Hs Code.:

Synonyms:tert-butyl 4-[(hydroxyamino)carbonyl]-4-{[(4-phenoxyphenyl)sulfonyl]methyl}piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-[(hydroxyamino)carbonyl]-4-{[(4-phenoxyphenyl)sulfonyl]methyl}piperidine-1-carboxylate

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Technology Process of tert-butyl 4-[(hydroxyamino)carbonyl]-4-{[(4-phenoxyphenyl)sulfonyl]methyl}piperidine-1-carboxylate

There total 5 articles about tert-butyl 4-[(hydroxyamino)carbonyl]-4-{[(4-phenoxyphenyl)sulfonyl]methyl}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 869063-72-9
4-(4-phenoxy-benzenesulfonylmethyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

: 213013-88-8
tert-butyl 4-[(hydroxyamino)carbonyl]-4-{[(4-phenoxyphenyl)sulfonyl]methyl}piperidine-1-carboxylate

Guidance literature:: With hydroxylamine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 4-methyl-morpholine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/jm0500875

Reference yield:

: 213013-98-0
4-(iodomethyl)piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

: 213013-88-8
tert-butyl 4-[(hydroxyamino)carbonyl]-4-{[(4-phenoxyphenyl)sulfonyl]methyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / dimethylformamide / 0.25 h / 0 °C

1.2: 89 percent / dimethylformamide / 4 h / 0 - 20 °C

2.1: 97 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 2 h / 0 °C

3.1: 100 percent / aq. NaOH / ethanol; tetrahydrofuran / 18 h / 60 °C

4.1: 34 percent / aq. hydroxylamine; HOBt; EDC / NMM / dimethylformamide / 16 h / 20 °C

With sodium hydroxide; hydroxylamine; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 3-chloro-benzenecarboperoxoic acid; 4-methyl-morpholine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0500875

Reference yield:

: 213014-03-0
4-(4-phenoxy-phenylsulfanylmethyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

: 213013-88-8
tert-butyl 4-[(hydroxyamino)carbonyl]-4-{[(4-phenoxyphenyl)sulfonyl]methyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 2 h / 0 °C

2: 100 percent / aq. NaOH / ethanol; tetrahydrofuran / 18 h / 60 °C

3: 34 percent / aq. hydroxylamine; HOBt; EDC / NMM / dimethylformamide / 16 h / 20 °C

With sodium hydroxide; hydroxylamine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 3-chloro-benzenecarboperoxoic acid; 4-methyl-morpholine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0500875