1-tert-butyl 4-ethyl 4-{[(4-phenoxyphenyl)sulfonyl]methyl}piperidine-1,4-dicarboxylate

Base Information

Chemical Name:1-tert-butyl 4-ethyl 4-{[(4-phenoxyphenyl)sulfonyl]methyl}piperidine-1,4-dicarboxylate
CAS No.:213014-04-1
Molecular Formula:C₂₆H₃₃NO₇S
Molecular Weight:503.617
Hs Code.:

Synonyms:1-tert-butyl 4-ethyl 4-{[(4-phenoxyphenyl)sulfonyl]methyl}piperidine-1,4-dicarboxylate

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Chemical Property of 1-tert-butyl 4-ethyl 4-{[(4-phenoxyphenyl)sulfonyl]methyl}piperidine-1,4-dicarboxylate

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Technology Process of 1-tert-butyl 4-ethyl 4-{[(4-phenoxyphenyl)sulfonyl]methyl}piperidine-1,4-dicarboxylate

There total 3 articles about 1-tert-butyl 4-ethyl 4-{[(4-phenoxyphenyl)sulfonyl]methyl}piperidine-1,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 213014-03-0
4-(4-phenoxy-phenylsulfanylmethyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

: 213014-04-1
1-tert-butyl 4-ethyl 4-{[(4-phenoxyphenyl)sulfonyl]methyl}piperidine-1,4-dicarboxylate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1021/jm0500875

Reference yield:

: 213013-98-0
4-(iodomethyl)piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

: 213014-04-1
1-tert-butyl 4-ethyl 4-{[(4-phenoxyphenyl)sulfonyl]methyl}piperidine-1,4-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.25 h / 0 °C

1.2: 89 percent / dimethylformamide / 4 h / 0 - 20 °C

2.1: 97 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 2 h / 0 °C

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0500875

Reference yield:

: 142851-03-4
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

: 213014-04-1
1-tert-butyl 4-ethyl 4-{[(4-phenoxyphenyl)sulfonyl]methyl}piperidine-1,4-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran / 0.5 h / -40 °C

1.2: 96.8 percent / tetrahydrofuran

2.1: NaH / dimethylformamide / 0.25 h / 0 °C

2.2: 89 percent / dimethylformamide / 4 h / 0 - 20 °C

3.1: 97 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 2 h / 0 °C

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0500875