N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-7-yl]-4-(4-phenylbutoxy)benzamide

Base Information Edit

Chemical Name:N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-7-yl]-4-(4-phenylbutoxy)benzamide
CAS No.:103177-37-3
Molecular Formula:C27H23N5O4
Molecular Weight:481.511
Hs Code.:
ChEMBL ID:CHEMBL1085767
Mol file:103177-37-3.mol

Synonyms:SCHEMBL3694;CHEMBL1085767;SCHEMBL15547055;BDBM85674;AMY8864;HMS3651A21;PDSP1_000179;PDSP2_000178;s1829;AKOS026749929;N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-7-yl]-4-(4-phenylbutoxy)benzamide;CCG-269560;NSC_115100;NCGC00181765-02;CAS_103177-37-3;SW219912-1;AB01566882_01;L000493;J-000887;N-[4-oxo-2-(2H-1,2,3,4-tetrazol-5-yl)-4H-chromen-7-yl]-4-(4-phenylbutoxy)benzamide

Suppliers and Price of N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-7-yl]-4-(4-phenylbutoxy)benzamide

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Pranlukast
100mg
$ 389.00

TRC
Pranlukast
10mg
$ 50.00

TRC
Pranlukast
100mg
$ 100.00

Tocris
ONO1078 ≥99%(HPLC)
50
$ 105.00

TCI Chemical
Pranlukast >98.0%(HPLC)
100mg
$ 99.00

TCI Chemical
Pranlukast >98.0%(HPLC)
25mg
$ 36.00

Medical Isotopes, Inc.
Pranlukast-d4
1 mg
$ 890.00

Medical Isotopes, Inc.
Pranlukast
0.5 g
$ 1760.00

DC Chemicals
Pranlukast >99%
250 mg
$ 500.00

CSNpharm
Pranlukast
100mg
$ 110.00

Total 143 raw suppliers

Chemical Property of N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-7-yl]-4-(4-phenylbutoxy)benzamide Edit

Chemical Property:

Appearance/Colour:off-white solid
Melting Point:236-238 °C
Refractive Index:1.68
PKA:4.96±0.10(Predicted)
PSA：123.00000
Density:1.374 g/cm³
LogP:4.70010
Storage Temp.:Store at +4°C
Solubility.:Soluble in DMSO (up to 25 mg/ml)
XLogP3:4.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:9
Exact Mass:481.17500423
Heavy Atom Count:36
Complexity:778

Purity/Quality:

99% ^*data from raw suppliers

Pranlukast ^*data from reagent suppliers

Safty Information:

Pictogram(s): F, C
Hazard Codes:F,C
Statements: 11-34
Safety Statements: 16-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1=CC=C(C=C1)CCCCOC2=CC=C(C=C2)C(=O)NC3=CC4=C(C=C3)C(=O)C=C(O4)C5=NNN=N5
Description Pranlukast, a novel chromone derivative, was introduced in Japan for the treatment of bronchial asthma and allergic diseases. Pranlukast is a highly potent, selective and competitive antagonist of peptidoleukotrienes with high affinity for the LTD4 receptor. In patients with bronchial asthma, pranlukast was reported to induce significant improvement in both immediate and late asthmatic response induced by antigen. Pranlukast is also being evaluated clinically for the treatment of perennial allergic rhinitis, pediatric asthma, and cutaneous pruritus in dialysis patients. The therapeutic potential of pranlukast in managing irritable bowel syndrome has been suggested.
Uses A potent, selective and orally active CysLT receptor antagonist. Leukotriene antagonist. Used as an antiasthmatic antiasthmatic;leukotriene receptor-1 antagonist Labeled Pranlukast, intended for use as an internal standard for the quantification of Pranlukast by GC- or LC-mass spectrometry.

Technology Process of N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-7-yl]-4-(4-phenylbutoxy)benzamide

There total 22 articles about N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-7-yl]-4-(4-phenylbutoxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%