136450-11-8

Basic information

• Product Name: N-(2-Cyano-4-oxo-4H-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzamide
• Synonyms: N-(2-Cyano-4-oxo-4H-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzamide;N-(2-cyano-4-oxo-4H-chromen-8-yl)-4-(4-phenylbutoxy)benzamide;N-(2-cyano-4-oxochromen-8-yl)-4-(4-phenylbutoxy)benzamide
• CAS NO: 136450-11-8
• Molecular Formula: C₂₇H₂₂N₂O₄
• Molecular Weight: 438.47
• Mol File: 136450-11-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 574.009 °C at 760 mmHg
• Flash Point: 300.95 °C
• Appearance: /
• Density: 1.30
• CAS DataBase Reference: N-(2-Cyano-4-oxo-4H-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Cyano-4-oxo-4H-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzamide(136450-11-8)
• EPA Substance Registry System: N-(2-Cyano-4-oxo-4H-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzamide(136450-11-8)

Safety Data

• Hazardous Substances Data: 136450-11-8(Hazardous Substances Data)

Usage

General Description

N-(2-Cyano-4-oxo-4H-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzamide, also known as BAY 11-7082, is a synthetic compound that has been studied for its potential pharmaceutical properties. It belongs to the class of compounds known as benzamides, which have been researched for their anti-inflammatory, anti-cancer, and neuroprotective effects. BAY 11-7082 is known to inhibit the activation of the transcription factor NF-κB, which plays a crucial role in inflammatory and immune responses. As a result, this compound has been investigated for its potential use in the treatment of various diseases, such as cancer, neurodegenerative disorders, and inflammatory conditions. Further research is ongoing to explore the therapeutic potential of BAY 11-7082 and its derivatives.

Upstream product

• 104-90-5 5-ethyl-2-methyl-pyridine 
• 136450-10-7 4-Oxo-8-((4-(4-phenylbutoxy)phenyl)carbonylamino)chromene-2-carboxamide 

Downstream Products

• 103177-37-3 (N-[4-oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)benzamide) 

Relevant articles and documents

Industrial preparation method of anti-asthma drug pranlukast intermediate

The invention discloses a preparation method of a pranlukast intermediate N-(2-cyano-4-oxo-4H-chromene-8-yl)-4-(4-butoxyphenyl)benzamide (short for formula I), specifically a method for preparing N-(2-cyano-4-oxo-4H-chromene-8-yl)-4-(4-butoxyphenyl)benzamide by carrying out a dewatering reaction on 4-oxo-8-[4-(4-butoxyphenyl)benzamide]-4H-chromene-2-formamide (short for formula II). The preparation method of the pranlukast intermediate represented by the formula I is high in yield, good in product color, high in product purity and beneficial to industrial production.

A process for the preparation of nitrile compounds used as intermediates in the synthesis of cysteinyl leukotrienes antagonists

A process for the preparation of a compound of formula (I) or a salt thereof wherein R is an amino, nitro or -NHCOR1 group, wherein R1 is C1-C6 alkyl or phenyl optionally substituted by a -O-(CH2)su

PROCESS FOR PRODUCING NITRILE COMPOUND

Processes for the preparation of the nitrile compound of formula (1). According to the present invention, the compound of formula (I) can be prepared cheaply and simply, therefore, the present invention is excellent as the industrial mass production metho