Methanesulfonic acid (1R,2R)-4-benzyloxy-1-(2-cyano-ethyl)-2-methyl-butyl ester

Base Information

Chemical Name:Methanesulfonic acid (1R,2R)-4-benzyloxy-1-(2-cyano-ethyl)-2-methyl-butyl ester
CAS No.:182949-19-5
Molecular Formula:C₁₆H₂₃NO₄S
Molecular Weight:325.429
Hs Code.:

Synonyms:Methanesulfonic acid (1R,2R)-4-benzyloxy-1-(2-cyano-ethyl)-2-methyl-butyl ester

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Chemical Property of Methanesulfonic acid (1R,2R)-4-benzyloxy-1-(2-cyano-ethyl)-2-methyl-butyl ester

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Technology Process of Methanesulfonic acid (1R,2R)-4-benzyloxy-1-(2-cyano-ethyl)-2-methyl-butyl ester

There total 8 articles about Methanesulfonic acid (1R,2R)-4-benzyloxy-1-(2-cyano-ethyl)-2-methyl-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 124-63-0
methanesulfonyl chloride

: 182949-18-4
(4R,5R)-7-Benzyloxy-4-hydroxy-5-methyl-heptanenitrile

: 182949-19-5
Methanesulfonic acid (1R,2R)-4-benzyloxy-1-(2-cyano-ethyl)-2-methyl-butyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1039/p19960002291

Reference yield:

: 144781-81-7
methyl (3S,4R)-4-(tert-butyldimethylsiloxy)-3,7-dimethyl-6-octenoate

: 182949-19-5
Methanesulfonic acid (1R,2R)-4-benzyloxy-1-(2-cyano-ethyl)-2-methyl-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 93 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

2: 100 percent / NaH / dimethylformamide / 2 h / Ambient temperature

3: 1.) O₃, 2.) PPh₃ / 1.) MeOH, -78 deg C, 10 min, 2.) -78 deg C to r.t.

4: 87 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

5: 99 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

6: 86 percent / dimethylsulfoxide / 6 h / 60 °C

7: 99 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

With lithium aluminium tetrahydride; sodium hydride; ozone; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1039/p19960002291

Reference yield:

: 144781-72-6
(1R,2R,3R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(1-chloro-1-methyl-ethyl)-2-methyl-cyclopentanecarboxylic acid methyl ester

: 182949-19-5
Methanesulfonic acid (1R,2R)-4-benzyloxy-1-(2-cyano-ethyl)-2-methyl-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: SmI₂ / tetrahydrofuran; hexamethylphosphoric acid triamide / Ambient temperature

2: 93 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

3: 100 percent / NaH / dimethylformamide / 2 h / Ambient temperature

4: 1.) O₃, 2.) PPh₃ / 1.) MeOH, -78 deg C, 10 min, 2.) -78 deg C to r.t.

5: 87 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

6: 99 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

7: 86 percent / dimethylsulfoxide / 6 h / 60 °C

8: 99 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

With lithium aluminium tetrahydride; samarium diiodide; sodium hydride; ozone; triethylamine; triphenylphosphine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1039/p19960002291