2-propyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pent-4-ynamide

Base Information

• Chemical Name: 2-propyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pent-4-ynamide
• CAS No.: 1425052-62-5
• Molecular Formula: C₁₅H₁₂F₇NO
• Molecular Weight: 355.255
• Mol file: 1425052-62-5.mol

Synonyms:2-propyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pent-4-ynamide

Chemical Property of 2-propyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pent-4-ynamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-propyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pent-4-ynamide

There total 2 articles about 2-propyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pent-4-ynamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C21H26F7NOSi (1425052-58-9) → 2-propyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pent-4-ynamide (1425052-62-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 6h; Schlenk technique; Inert atmosphere;

DOI:10.1021/ja400648w

Reference yield:

2-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pentanamide (1217507-32-8) → 2-propyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pent-4-ynamide (1425052-62-5)

Guidance literature:

Multi-step reaction with 2 steps

1: bis(η3-allyl-μ-chloropalladium(II)); C23H33N2(1+)*BF4(1-); caesium carbonate / diethyl ether / 8.08 h / 20 - 85 °C / Schlenk technique; Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 °C / Schlenk technique; Inert atmosphere

With bis(η3-allyl-μ-chloropalladium(II)); C₂₃H₃₃N₂⁽¹⁺⁾*BF₄^(1-); tetrabutyl ammonium fluoride; caesium carbonate; In tetrahydrofuran; diethyl ether;

DOI:10.1021/ja400648w

upstream raw materials:

2-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pentanamide

C₂₁H₂₆F₇NOSi