2-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pentanamide

Base Information

• Chemical Name: 2-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pentanamide
• CAS No.: 1217507-32-8
• Molecular Formula: C₁₃H₁₂F₇NO
• Molecular Weight: 331.233
• Mol file: 1217507-32-8.mol

Synonyms:2-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pentanamide

Chemical Property of 2-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pentanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pentanamide

There total 1 articles about 2-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methylvaleryl chloride (116908-84-0,5238-27-7) + 4-trifluoromethyl-2,3,5,6-tetrafluoroaniline (651-83-2) → 2-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pentanamide (1217507-32-8)

Guidance literature:

In toluene; at 20 ℃; for 16h; Reflux;

DOI:10.1021/ja1010866

Reference yield: 81.0%

2-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pentanamide (1217507-32-8) + 1-bromo-2-(triisopropylsilyl)acetylene (111409-79-1) → 2-propyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)-5-(triisopropylsilyl)pent-4-ynamide (1425052-44-3)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); C₂₃H₃₃N₂⁽¹⁺⁾*BF₄^(1-); caesium carbonate; In diethyl ether; at 20 - 85 ℃; for 8.08333h; Reagent/catalyst; Solvent; Time; Temperature; Schlenk technique; Inert atmosphere;

DOI:10.1021/ja400648w

Reference yield: 75.0%

2-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pentanamide (1217507-32-8) + 1-bromo-2-(tert-butyldimethylsilyl)acetylene (708208-01-9) → C21H26F7NOSi (1425052-58-9)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); C₂₃H₃₃N₂⁽¹⁺⁾*BF₄^(1-); caesium carbonate; In diethyl ether; at 20 - 85 ℃; for 8.08333h; Schlenk technique; Inert atmosphere;

DOI:10.1021/ja400648w

upstream raw materials:

2-methylvaleryl chloride

4-trifluoromethyl-2,3,5,6-tetrafluoroaniline

Downstream raw materials:

3-propyl-1-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pyrrolidine-2,5-dione

2-propyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pent-4-ynamide

(Z)-5-(prop-2-yn-1-ylidene)-3-propyl-1-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pyrrolidin-2-one

2-propyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)-5-(triisopropylsilyl)pent-4-ynamide