2-(4-(3-benzoyl-8-chloro-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Base Information

Chemical Name:2-(4-(3-benzoyl-8-chloro-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile
CAS No.:1260167-93-8
Molecular Formula:C₂₇H₁₉ClN₄O₂
Molecular Weight:466.926
Hs Code.:

Synonyms:2-(4-(3-benzoyl-8-chloro-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-(3-benzoyl-8-chloro-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(4-(3-benzoyl-8-chloro-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

There total 9 articles about 2-(4-(3-benzoyl-8-chloro-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 618-32-6
Benzoyl bromide

: 1260167-17-6
2-(4-(8-chloro-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methyl propanenitrile

: 1260167-93-8
2-(4-(3-benzoyl-8-chloro-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: 2-(4-(8-chloro-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methyl propanenitrile; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h; Inert atmosphere;

Benzoyl bromide; In N,N-dimethyl-formamide;

Reference yield:

: 115279-57-7
2-(4-aminophenyl)-2-methylpropionitrile

: 1260167-93-8
2-(4-(3-benzoyl-8-chloro-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / 2 h

2: hydrogen / Raney-Ni / tetrahydrofuran; methanol / 3 h / 20 °C / 1292.9 Torr

3: triethylamine / dichloromethane / 1 h / 0 °C

4: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere

With hydrogen; sodium hydride; triethylamine; Raney-Ni; In tetrahydrofuran; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 71825-51-9
4-(2-cyanoprop-2-yl)-1-nitrobenzene

: 1260167-93-8
2-(4-(3-benzoyl-8-chloro-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / Raney-Ni / tetrahydrofuran; methanol / 10 h / 20 °C / 2068.65 Torr

2: acetic acid / 2 h

3: hydrogen / Raney-Ni / tetrahydrofuran; methanol / 3 h / 20 °C / 1292.9 Torr

4: triethylamine / dichloromethane / 1 h / 0 °C

5: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere

With hydrogen; sodium hydride; triethylamine; Raney-Ni; In tetrahydrofuran; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;