(E)-2-(2-((4-(trifluoromethyl)phenyl)imino)propanamido)phenyl trifluoromethanesulfonate

Base Information

• Chemical Name: (E)-2-(2-((4-(trifluoromethyl)phenyl)imino)propanamido)phenyl trifluoromethanesulfonate
• CAS No.: 1396630-29-7
• Molecular Formula: C₁₇H₁₂F₆N₂O₄S
• Molecular Weight: 454.35
• Mol file: 1396630-29-7.mol

Synonyms:(E)-2-(2-((4-(trifluoromethyl)phenyl)imino)propanamido)phenyl trifluoromethanesulfonate

Chemical Property of (E)-2-(2-((4-(trifluoromethyl)phenyl)imino)propanamido)phenyl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-(2-((4-(trifluoromethyl)phenyl)imino)propanamido)phenyl trifluoromethanesulfonate

There total 4 articles about (E)-2-(2-((4-(trifluoromethyl)phenyl)imino)propanamido)phenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

4-trifluoromethylphenylamine (455-14-1) + trifluoromethanesulfonic acid 2-(2-oxo-propionylamido)phenyl ester (1334682-26-6) → (E)-2-(2-((4-(trifluoromethyl)phenyl)imino)propanamido)phenyl trifluoromethanesulfonate (1396630-29-7)

Guidance literature:

With sodium hydrogencarbonate; In toluene; at 50 ℃; for 67h; Molecular sieve; Inert atmosphere; Sealed tube;

DOI:10.1021/ol302119j DOI:10.1021/ol302119j

Reference yield:

2-nitrophenyl trifluoromethanesulfonate (132993-22-7) → (E)-2-(2-((4-(trifluoromethyl)phenyl)imino)propanamido)phenyl trifluoromethanesulfonate (1396630-29-7)

Guidance literature:

Multi-step reaction with 3 steps

1: iron; acetic acid / ethanol / 5 h / Reflux; Inert atmosphere

2: dicyclohexyl-carbodiimide / chloroform / 3 h / 0 °C / Inert atmosphere

3: sodium hydrogencarbonate / toluene / 67 h / 50 °C / Molecular sieve; Inert atmosphere; Sealed tube

With iron; sodium hydrogencarbonate; acetic acid; dicyclohexyl-carbodiimide; In ethanol; chloroform; toluene;

DOI:10.1021/ol302119j DOI:10.1021/ol302119j

Reference yield:

2-hydroxynitrobenzene (88-75-5,78813-12-4) → (E)-2-(2-((4-(trifluoromethyl)phenyl)imino)propanamido)phenyl trifluoromethanesulfonate (1396630-29-7)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: iron; acetic acid / ethanol / 5 h / Reflux; Inert atmosphere

3: dicyclohexyl-carbodiimide / chloroform / 3 h / 0 °C / Inert atmosphere

4: sodium hydrogencarbonate / toluene / 67 h / 50 °C / Molecular sieve; Inert atmosphere; Sealed tube

With iron; sodium hydrogencarbonate; acetic acid; triethylamine; dicyclohexyl-carbodiimide; In ethanol; dichloromethane; chloroform; toluene;

DOI:10.1021/ol302119j DOI:10.1021/ol302119j

upstream raw materials:

2-hydroxynitrobenzene

2-nitrophenyl trifluoromethanesulfonate

2-(aminophenyl)trifluoromethanesulfonate

4-trifluoromethylphenylamine

Downstream raw materials:

(S)-3-methyl-3-((4-(trifluoromethyl)phenyl)amino)indolin-2-one

3-methyl-3-((4-(trifluoromethyl)phenyl)amino)indolin-2-one