5-chloro-N-{1-[2-(biphenyl-2-yloxy)ethyl]piperidin-4-yl}thiophene-2-sulfonamide

Base Information

Chemical Name:5-chloro-N-{1-[2-(biphenyl-2-yloxy)ethyl]piperidin-4-yl}thiophene-2-sulfonamide
CAS No.:1414264-34-8
Molecular Formula:C₂₃H₂₅ClN₂O₃S₂
Molecular Weight:477.048
Hs Code.:

Synonyms:5-chloro-N-{1-[2-(biphenyl-2-yloxy)ethyl]piperidin-4-yl}thiophene-2-sulfonamide

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Chemical Property of 5-chloro-N-{1-[2-(biphenyl-2-yloxy)ethyl]piperidin-4-yl}thiophene-2-sulfonamide

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Technology Process of 5-chloro-N-{1-[2-(biphenyl-2-yloxy)ethyl]piperidin-4-yl}thiophene-2-sulfonamide

There total 4 articles about 5-chloro-N-{1-[2-(biphenyl-2-yloxy)ethyl]piperidin-4-yl}thiophene-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 2766-74-7
5-chlorothien-2-ylsulfonyl chloride

: C₁₉H₂₄N₂O

: 1414264-34-8
5-chloro-N-{1-[2-(biphenyl-2-yloxy)ethyl]piperidin-4-yl}thiophene-2-sulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; Cooling with ice;
DOI:10.1039/c5md00166h

Reference yield:

: t-butyl {1-[2-(biphenyl-2-yloxy)ethyl]piperidin-4-yl}carbamate

: 1414264-34-8
5-chloro-N-{1-[2-(biphenyl-2-yloxy)ethyl]piperidin-4-yl}thiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: triethylamine / dichloromethane / 0 °C / Cooling with ice

With triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1039/c5md00166h

Reference yield:

: 90-43-7,287950-96-3
2-Phenylphenol

: 1414264-34-8
5-chloro-N-{1-[2-(biphenyl-2-yloxy)ethyl]piperidin-4-yl}thiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; potassium iodide / acetone / 60 °C

2: potassium carbonate; potassium iodide / acetone / 72 h / 60 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4: triethylamine / dichloromethane / 0 °C / Cooling with ice

With potassium carbonate; triethylamine; trifluoroacetic acid; potassium iodide; In dichloromethane; acetone;
DOI:10.1039/c5md00166h