5-Chlorothiophene-2-sulfonyl chloride

Base Information

• Chemical Name: 5-Chlorothiophene-2-sulfonyl chloride
• CAS No.: 2766-74-7
• Molecular Formula: C4H2Cl2O2S2
• Molecular Weight: 217.097
• Hs Code.: 29349990
• European Community (EC) Number: 700-248-6,608-123-7
• DSSTox Substance ID: DTXSID30370041
• Nikkaji Number: J364.676I
• Wikidata: Q72459961
• Mol file: 2766-74-7.mol

Synonyms:2-Chloro-5-chlorosulfonylthiophene;2-Chlorothiophene-5-sulfonyl chloride;5-Chloro-2-thienylsulfonyl chloride;5-Chloro-2-thiophenesulfonyl chloride;

Chemical Property of 5-Chlorothiophene-2-sulfonyl chloride

Chemical Property:

• Appearance/Colour: white to yellow crystalline low melting solid
• Melting Point: 25-28 °C
• Refractive Index: n20/D 1.586(lit.)
• Boiling Point: 112-117 °C(lit.)
• Flash Point: >230 °F
• PSA: 70.76000
• Density: 1.623 g/mL at 25 °C(lit.)
• LogP: 3.40980
• Storage Temp.: Keep Cold
• Sensitive.: Moisture Sensitive
• Water Solubility.: Not miscible in water.
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 215.8873270
• Heavy Atom Count: 10
• Complexity: 208

Purity/Quality:

99% ^*data from raw suppliers

5-Chloro-2-thiophenesulfonyl Chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34-29-14
• Safety Statements: 26-27-36/37/39-45-28A-25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(SC(=C1)Cl)S(=O)(=O)Cl
• Uses: 5-Chloro-2-thiophenesulfonyl Chloride is a sulfonylthiophene derivative used in the preparation of Notch-1-sparing γ-secretase inhibitors for the treatment of Alzheimer's disease. 5-Chlorothiophene-2-sulfonyl chloride is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuffs. It is used in the preparation of Notch-1-sparing γ-secretase inhibitors for the treatment of Alzheimer's disease.

Technology Process of 5-Chlorothiophene-2-sulfonyl chloride

There total 3 articles about 5-Chlorothiophene-2-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-thienyl chloride (96-43-5) → 5-chlorothien-2-ylsulfonyl chloride (2766-74-7)

Guidance literature:

With chlorosulfonic acid; phosphorus pentachloride; at 0 - 20 ℃;

Reference yield:

2-chlorothiophene → 5-chlorothien-2-ylsulfonyl chloride (2766-74-7)

Guidance literature:

With chlorosulfonic acid; phosphorus pentachloride;

Reference yield:

→ 5-chlorothien-2-ylsulfonyl chloride (2766-74-7)

Guidance literature:

upstream raw materials:

2-thienyl chloride

Downstream raw materials:

N-phenyl-5-chloro-2-thiophenesulfonyl amide

5-chloro-4-nitro-2-thiophenesulfonyl chloride

N-(tert-butyl)-5-chloro-2-thiophenesulfonamide

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