7-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-7-deaza-2‘-deoxyadenosine-5‘-triphosphate

Base Information

Chemical Name:7-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-7-deaza-2‘-deoxyadenosine-5‘-triphosphate
CAS No.:1427311-56-5
Molecular Formula:C₂₇H₃₇N₆O₁₆P₃
Molecular Weight:794.543
Hs Code.:

Synonyms:7-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-7-deaza-2‘-deoxyadenosine-5‘-triphosphate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-7-deaza-2‘-deoxyadenosine-5‘-triphosphate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 7-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-7-deaza-2‘-deoxyadenosine-5‘-triphosphate

There total 16 articles about 7-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-7-deaza-2‘-deoxyadenosine-5‘-triphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₃₆F₃N₆O₁₇P₃

: 1427311-56-5
7-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-7-deaza-2‘-deoxyadenosine-5‘-triphosphate

Guidance literature:: With ammonium hydroxide; In water; at 20 ℃; for 1h;

Reference yield:

: 766-85-8
3-methoxy-1-iodobenzene

: 1427311-56-5
7-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-7-deaza-2‘-deoxyadenosine-5‘-triphosphate

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium nitrite; acetic acid; nitric acid / 24 h / 20 °C

1.2: 60 °C

2.1: phenylmagnesium chloride / tetrahydrofuran / 2 h / -40 °C / Inert atmosphere

2.2: 3 h / -30 - 20 °C / Inert atmosphere

2.3: Inert atmosphere

3.1: dmap / dichloromethane / 20 °C / Inert atmosphere

4.1: ethanol / Reflux

5.1: potassium carbonate; methanol / 1 h / Reflux

6.1: 0.75 h / 115 °C / Inert atmosphere

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

8.1: ammonia / 1,4-dioxane; methanol / 24 h / 100 °C / Sealed tube

9.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 24 h / 50 °C

10.1: trichlorophosphate; trimethyl phosphite; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 3 h / 0 °C / Inert atmosphere

10.2: 0.17 h / 20 °C / Inert atmosphere

10.3: 3407 / 1 h / 20 °C / pH 7.5 / Inert atmosphere

11.1: ammonium hydroxide / water / 1 h / 20 °C

With trimethyl phosphite; methanol; dmap; ammonium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; phenylmagnesium chloride; tetrabutyl ammonium fluoride; ammonia; nitric acid; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; potassium carbonate; acetic acid; triethylamine; sodium nitrite; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1427311-72-5
(R/S)-1-(4-iodo-5-methoxy-2-nitrophenyl)-2,2-dimethyl-1-propanol

: 1427311-56-5
7-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-7-deaza-2‘-deoxyadenosine-5‘-triphosphate

Guidance literature:: Multi-step reaction with 9 steps

1.1: dmap / dichloromethane / 20 °C / Inert atmosphere

2.1: ethanol / Reflux

3.1: potassium carbonate; methanol / 1 h / Reflux

4.1: 0.75 h / 115 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

6.1: ammonia / 1,4-dioxane; methanol / 24 h / 100 °C / Sealed tube

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 24 h / 50 °C

8.1: trichlorophosphate; trimethyl phosphite; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 3 h / 0 °C / Inert atmosphere

8.2: 0.17 h / 20 °C / Inert atmosphere

8.3: 3407 / 1 h / 20 °C / pH 7.5 / Inert atmosphere

9.1: ammonium hydroxide / water / 1 h / 20 °C

With trimethyl phosphite; methanol; dmap; ammonium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; ammonia; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; potassium carbonate; triethylamine; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;