(E)-(11R,13S,15aS)-4,15-Dioxo-2,3,4,5,7,10,11,12,13,14,15,15a-dodecahydro-1H-3a,6,14-triaza-cyclopentacyclotetradecene-6,11,13-tricarboxylic acid tribenzyl ester

Base Information

Chemical Name:(E)-(11R,13S,15aS)-4,15-Dioxo-2,3,4,5,7,10,11,12,13,14,15,15a-dodecahydro-1H-3a,6,14-triaza-cyclopentacyclotetradecene-6,11,13-tricarboxylic acid tribenzyl ester
CAS No.:765313-74-4
Molecular Formula:C₃₈H₄₁N₃O₈
Molecular Weight:667.759
Hs Code.:

(E)-(11R,13S,15aS)-4,15-Dioxo-2,3,4,5,7,10,11,12,13,14,15,15a-dodecahydro-1H-3a,6,14-triaza-cyclopentacyclotetradecene-6,11,13-tricarboxylic acid tribenzyl ester

Synonyms:(E)-(11R,13S,15aS)-4,15-Dioxo-2,3,4,5,7,10,11,12,13,14,15,15a-dodecahydro-1H-3a,6,14-triaza-cyclopentacyclotetradecene-6,11,13-tricarboxylic acid tribenzyl ester

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Chemical Property of (E)-(11R,13S,15aS)-4,15-Dioxo-2,3,4,5,7,10,11,12,13,14,15,15a-dodecahydro-1H-3a,6,14-triaza-cyclopentacyclotetradecene-6,11,13-tricarboxylic acid tribenzyl ester

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Technology Process of (E)-(11R,13S,15aS)-4,15-Dioxo-2,3,4,5,7,10,11,12,13,14,15,15a-dodecahydro-1H-3a,6,14-triaza-cyclopentacyclotetradecene-6,11,13-tricarboxylic acid tribenzyl ester

There total 3 articles about (E)-(11R,13S,15aS)-4,15-Dioxo-2,3,4,5,7,10,11,12,13,14,15,15a-dodecahydro-1H-3a,6,14-triaza-cyclopentacyclotetradecene-6,11,13-tricarboxylic acid tribenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 549521-87-1
N-allyl-N-benzyloxycarbonylglycyl-L-prolyl-L-γ-(R)-allylglutamic acid dibenzyl ester

: 765313-74-4
(E)-(11R,13S,15aS)-4,15-Dioxo-2,3,4,5,7,10,11,12,13,14,15,15a-dodecahydro-1H-3a,6,14-triaza-cyclopentacyclotetradecene-6,11,13-tricarboxylic acid tribenzyl ester

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In benzene; at 45 ℃; for 65h;
DOI:10.1021/ol034370e

Reference yield:

: (2S,4S)-2-Allyl-4-amino-pentanedioic acid dibenzyl ester

: 765313-74-4
(E)-(11R,13S,15aS)-4,15-Dioxo-2,3,4,5,7,10,11,12,13,14,15,15a-dodecahydro-1H-3a,6,14-triaza-cyclopentacyclotetradecene-6,11,13-tricarboxylic acid tribenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / EtOCOCl

2: PhCH=RuCl₂[P(cyclohexyl)3][N,N'-bis(Mes)imidazolidin-2-yl] / benzene / 65 h / 45 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; chloroformic acid ethyl ester; In benzene;
DOI:10.1021/ol034370e

Reference yield:

: 549521-86-0
N-allyl-N-benzyloxycarbonylglycyl-L-proline

: 765313-74-4
(E)-(11R,13S,15aS)-4,15-Dioxo-2,3,4,5,7,10,11,12,13,14,15,15a-dodecahydro-1H-3a,6,14-triaza-cyclopentacyclotetradecene-6,11,13-tricarboxylic acid tribenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / EtOCOCl

2: PhCH=RuCl₂[P(cyclohexyl)3][N,N'-bis(Mes)imidazolidin-2-yl] / benzene / 65 h / 45 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; chloroformic acid ethyl ester; In benzene;
DOI:10.1021/ol034370e