N-allyl-N-benzyloxycarbonylglycyl-L-prolyl-L-γ-(R)-allylglutamic acid dibenzyl ester

Base Information

Chemical Name:N-allyl-N-benzyloxycarbonylglycyl-L-prolyl-L-γ-(R)-allylglutamic acid dibenzyl ester
CAS No.:549521-87-1
Molecular Formula:C₄₀H₄₅N₃O₈
Molecular Weight:695.813
Hs Code.:

Synonyms:N-allyl-N-benzyloxycarbonylglycyl-L-prolyl-L-γ-(R)-allylglutamic acid dibenzyl ester

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Chemical Property of N-allyl-N-benzyloxycarbonylglycyl-L-prolyl-L-γ-(R)-allylglutamic acid dibenzyl ester

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Technology Process of N-allyl-N-benzyloxycarbonylglycyl-L-prolyl-L-γ-(R)-allylglutamic acid dibenzyl ester

There total 4 articles about N-allyl-N-benzyloxycarbonylglycyl-L-prolyl-L-γ-(R)-allylglutamic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: (2S,4S)-2-Allyl-4-amino-pentanedioic acid dibenzyl ester

: 549521-86-0
N-allyl-N-benzyloxycarbonylglycyl-L-proline

: 549521-87-1
N-allyl-N-benzyloxycarbonylglycyl-L-prolyl-L-γ-(R)-allylglutamic acid dibenzyl ester

Guidance literature:: With chloroformic acid ethyl ester;
DOI:10.1021/ol034370e

Reference yield:

: (2S,4S)-2-Allyl-4-amino-pentanedioic acid dibenzyl ester; compound with trifluoro-acetic acid

: 549521-86-0
N-allyl-N-benzyloxycarbonylglycyl-L-proline

: 549521-87-1
N-allyl-N-benzyloxycarbonylglycyl-L-prolyl-L-γ-(R)-allylglutamic acid dibenzyl ester

Guidance literature:: N-allyl-N-benzyloxycarbonylglycyl-L-proline; With chloroformic acid ethyl ester; triethylamine; In dichloromethane; at 0 ℃; for 0.666667h;

(2S,4S)-2-Allyl-4-amino-pentanedioic acid dibenzyl ester; compound with trifluoro-acetic acid; With triethylamine; In dichloromethane; Further stages.;
DOI:10.1039/b605293b

Reference yield:

: 765313-72-2
N-allyl-N-benzyloxycarbonylglycyl-L-proline methyl ester

: 549521-87-1
N-allyl-N-benzyloxycarbonylglycyl-L-prolyl-L-γ-(R)-allylglutamic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 55 percent / aq. NaOH / dioxane / 20 h / 20 °C

2.1: EtOCOCl; Et₃N / CH₂Cl₂ / 0.67 h / 0 °C

2.2: Et₃N / CH₂Cl₂

With sodium hydroxide; chloroformic acid ethyl ester; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1039/b605293b