2-methyl-4-(5-thiazolyl)-1(2H)-phthalazinone

Base Information

• Chemical Name: 2-methyl-4-(5-thiazolyl)-1(2H)-phthalazinone
• CAS No.: 137382-10-6
• Molecular Formula: C₁₂H₉N₃OS
• Molecular Weight: 243.289
• Mol file: 137382-10-6.mol

Synonyms:2-methyl-4-(5-thiazolyl)-1(2H)-phthalazinone

Chemical Property of 2-methyl-4-(5-thiazolyl)-1(2H)-phthalazinone

Chemical Property:

• Vapor Pressure: 1.17E-07mmHg at 25°C
• Boiling Point: 431.8°Cat760mmHg
• Flash Point: 214.9°C
• PSA: 76.02000
• Density: 1.41g/cm³
• LogP: 2.05700

Purity/Quality:

2-METHYL-4-(5-THIAZOLYL)-1(2H)-PHTHALAZINONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methyl-4-(5-thiazolyl)-1(2H)-phthalazinone

There total 3 articles about 2-methyl-4-(5-thiazolyl)-1(2H)-phthalazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phthalic anhydride (85-44-9) → 2-methyl-4-(5-thiazolyl)-1(2H)-phthalazinone (137382-10-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1.5 h, 2.) THF, hexane, -78 deg C, 1 h

2: 78 percent / 80percent N₂H₄*H₂O / ethanol / 3 h / Heating

3: 1.) NaH

With n-butyllithium; sodium hydride; hydrazine hydrate; In ethanol;

DOI:10.1021/jm00077a009

Reference yield:

2-(Thiazole-5-carbonyl)-benzoic acid (153078-00-3) → 2-methyl-4-(5-thiazolyl)-1(2H)-phthalazinone (137382-10-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / 80percent N₂H₄*H₂O / ethanol / 3 h / Heating

2: 1.) NaH

With sodium hydride; hydrazine hydrate; In ethanol;

DOI:10.1021/jm00077a009

Reference yield:

4-Thiazol-5-yl-2H-phthalazin-1-one (137382-08-2) + methyl iodide (74-88-4) → 2-methyl-4-(5-thiazolyl)-1(2H)-phthalazinone (137382-10-6)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction;

DOI:10.1021/jm00077a009

upstream raw materials:

4-Thiazol-5-yl-2H-phthalazin-1-one

methyl iodide

phthalic anhydride

2-(Thiazole-5-carbonyl)-benzoic acid