(S)-4-(3,5-dimethoxyphenyl)-2-methyl-1-butanol tosylate

Base Information

• Chemical Name: (S)-4-(3,5-dimethoxyphenyl)-2-methyl-1-butanol tosylate
• CAS No.: 187084-12-4
• Molecular Formula: C₂₀H₂₆O₅S
• Molecular Weight: 378.489
• Mol file: 187084-12-4.mol

Synonyms:(S)-4-(3,5-dimethoxyphenyl)-2-methyl-1-butanol tosylate

Chemical Property of (S)-4-(3,5-dimethoxyphenyl)-2-methyl-1-butanol tosylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-(3,5-dimethoxyphenyl)-2-methyl-1-butanol tosylate

There total 2 articles about (S)-4-(3,5-dimethoxyphenyl)-2-methyl-1-butanol tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

p-toluenesulfonyl chloride (98-59-9) + (S)-4-(3,5-dimethoxyphenyl)-2-methyl-1-butanol (187084-11-3) → (S)-4-(3,5-dimethoxyphenyl)-2-methyl-1-butanol tosylate (187084-12-4)

Guidance literature:

With pyridine; In chloroform; for 18h; Ambient temperature;

DOI:10.1016/S0040-4020(96)01134-9

Reference yield:

(S)-1-benzyloxy-4-(3,5-dimethoxyphenyl)-2-methylbutane (187083-86-9) → (S)-4-(3,5-dimethoxyphenyl)-2-methyl-1-butanol tosylate (187084-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / lithium, liq. NH₃ / diethyl ether / 0.5 h / -78 °C

2: 78 percent / pyridine / CHCl₃ / 18 h / Ambient temperature

With pyridine; ammonia; lithium; In diethyl ether; chloroform;

DOI:10.1016/S0040-4020(96)01134-9

Reference yield: 96.0%

methylmagnesium bromide (75-16-1) + (S)-4-(3,5-dimethoxyphenyl)-2-methyl-1-butanol tosylate (187084-12-4) → (R)-1-(3,5-dimethoxyphenyl)-3-methylpentane (187083-87-0)

Guidance literature:

With dilithium tetrachlorocuprate; In tetrahydrofuran; at -78 - 25 ℃;

DOI:10.1016/S0040-4020(96)01134-9

upstream raw materials:

p-toluenesulfonyl chloride

(S)-4-(3,5-dimethoxyphenyl)-2-methyl-1-butanol

(S)-1-benzyloxy-4-(3,5-dimethoxyphenyl)-2-methylbutane

Downstream raw materials:

(R)-1-(3,5-dimethoxyphenyl)-3-methylpentane

(R)-1-(3,5,-dimethoxyphenyl)-3-methylheptane