2-chloro-N-{6-chloro-1'-[(E)-3-(4-chloro-phenyl)-allyl]-5-fluoro-1',2',3',4',5',6'-hexahydro-[2,4l]bipyridinyl-3-yl}-isonicotinamide

Base Information

Chemical Name:2-chloro-N-{6-chloro-1'-[(E)-3-(4-chloro-phenyl)-allyl]-5-fluoro-1',2',3',4',5',6'-hexahydro-[2,4l]bipyridinyl-3-yl}-isonicotinamide
CAS No.:1196696-83-9
Molecular Formula:C₂₅H₂₂Cl₃FN₄O
Molecular Weight:519.833
Hs Code.:

Synonyms:2-chloro-N-{6-chloro-1'-[(E)-3-(4-chloro-phenyl)-allyl]-5-fluoro-1',2',3',4',5',6'-hexahydro-[2,4l]bipyridinyl-3-yl}-isonicotinamide

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Chemical Property of 2-chloro-N-{6-chloro-1'-[(E)-3-(4-chloro-phenyl)-allyl]-5-fluoro-1',2',3',4',5',6'-hexahydro-[2,4l]bipyridinyl-3-yl}-isonicotinamide

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Technology Process of 2-chloro-N-{6-chloro-1'-[(E)-3-(4-chloro-phenyl)-allyl]-5-fluoro-1',2',3',4',5',6'-hexahydro-[2,4l]bipyridinyl-3-yl}-isonicotinamide

There total 9 articles about 2-chloro-N-{6-chloro-1'-[(E)-3-(4-chloro-phenyl)-allyl]-5-fluoro-1',2',3',4',5',6'-hexahydro-[2,4l]bipyridinyl-3-yl}-isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1206539-37-8
2-chloro-N-(6-chloro-5-fluoro-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-3-yl)-isonicotinamide trifluoroacetate

: 103979-29-9
(E)-1-(4-chlorophenyl)-3-chloropropene

: 1196696-83-9
2-chloro-N-{6-chloro-1'-[(E)-3-(4-chloro-phenyl)-allyl]-5-fluoro-1',2',3',4',5',6'-hexahydro-[2,4l]bipyridinyl-3-yl}-isonicotinamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 - 50 ℃;

Reference yield:

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1196696-83-9
2-chloro-N-{6-chloro-1'-[(E)-3-(4-chloro-phenyl)-allyl]-5-fluoro-1',2',3',4',5',6'-hexahydro-[2,4l]bipyridinyl-3-yl}-isonicotinamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 1 h / Reflux

2: ammonium formate / palladium 10% on activated carbon / ethanol / 1.5 h / 20 °C

3: N-chloro-succinimide / 1-methyl-pyrrolidin-2-one / 1 h / 110 °C

4: sodium hydrogencarbonate / dichloromethane / 18 h / 20 °C

5: dichloromethane / 1.5 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 - 50 °C

With N-chloro-succinimide; ammonium formate; sodium hydrogencarbonate; sodium carbonate; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 884495-37-8
2-chloro-5-fluoro-3-nitropyridine

: 1196696-83-9
2-chloro-N-{6-chloro-1'-[(E)-3-(4-chloro-phenyl)-allyl]-5-fluoro-1',2',3',4',5',6'-hexahydro-[2,4l]bipyridinyl-3-yl}-isonicotinamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 1 h / Reflux

2: ammonium formate / palladium 10% on activated carbon / ethanol / 1.5 h / 20 °C

3: N-chloro-succinimide / 1-methyl-pyrrolidin-2-one / 1 h / 110 °C

4: sodium hydrogencarbonate / dichloromethane / 18 h / 20 °C

5: dichloromethane / 1.5 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 - 50 °C

With N-chloro-succinimide; ammonium formate; sodium hydrogencarbonate; sodium carbonate; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; acetonitrile;