884495-37-8

Basic information

• Product Name: 3-AMINO-2-CHLORO-5-FLUOROPYRIDINE
• Synonyms: 3-PyridinaMine,2-chloro-5-fluoro-;2-chloro-5-fluoro-3-PyridinaMine;2-Chloro-5-fluoro-pyridin-3-ylaMine;3-AMINO-2-CHLORO-5-FLUOROPYRIDINE
• CAS NO: 884495-37-8
• Molecular Formula: C5H4ClFN2
• Molecular Weight: 146.55
• Product Categories: Boronic Acid
• Mol File: 884495-37-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 250℃
• Flash Point: 105℃
• Appearance: /
• Density: 1.449
• Vapor Pressure: 0.0225mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 0.08±0.10(Predicted)
• CAS DataBase Reference: 3-AMINO-2-CHLORO-5-FLUOROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-2-CHLORO-5-FLUOROPYRIDINE(884495-37-8)
• EPA Substance Registry System: 3-AMINO-2-CHLORO-5-FLUOROPYRIDINE(884495-37-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 884495-37-8(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow powder

InChI:InChI=1/C5H4ClFN2/c6-5-4(8)1-3(7)2-9-5/h1-2H,8H2

Upstream product

• 185985-40-4 2,3-dichloro -5-fluoropyridine 
• 1394899-03-6 tert-butyl (2-chloro-5-fluoropyridin-3-yl)carbamate 
• 38186-88-8 2-chloro-5-fluoronicotinic acid 
• 136888-21-6 2-chloro-5-fluoro-3-nitro pyridine 
• 75302-64-6 2-chloro-5-fluoropyridine-3-carboxamide 

Downstream Products

• 185985-40-4 2,3-dichloro -5-fluoropyridine 
• 212268-12-7 2-amino-5-fluoro-3-nitropyridine 
• 136888-21-6 2-chloro-5-fluoro-3-nitro pyridine 
• 21717-96-4 2-amino-5-fluoropyridine 
• 1196696-83-9 2-chloro-N-{6-chloro-1'-[(E)-3-(4-chloro-phenyl)-allyl]-5-fluoro-1',2',3',4',5',6'-hexahydro-[2,4l]bipyridinyl-3-yl}-isonicotinamide 
• 959616-89-8 1-(2-(1-hydroxy-4-oxocyclohexyl)ethyl)-7-methoxy-1,5-naphthyridin-2(1H)-one 
• 1623153-66-1 1-(1-(2-(7-methoxy-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-phenylthiourea 
• 1623153-65-0 1-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-(p-tolyl)urea 
• 1623153-64-9 1-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-(4-methoxyphenyl)urea 
• 1623153-62-7 1-(4-acetylphenyl)-3-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)urea 
• 1623153-60-5 1-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-(4-nitrophenyl)urea 
• 1623153-59-2 1-(4-chlorophenyl)-3-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)urea 
• 1623153-58-1 1-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-(4-fluorophenyl)urea 
• 1623153-57-0 1-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-phenylurea 

Relevant articles and documents

INHIBITORS OF KEAP1-Nrf2 PROTEIN-PROTEIN INTERACTION

Sultam compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with the KEAP1-Nrf2 interaction, such as inflammatory bowel disease, including Crohn's disease and ulcerative colitis.

Triazole methyl ester linked spiro compound with antibacterial activity, and preparation method and application thereof

The invention discloses a triazole methyl ester linked spiro compound with antibacterial activity, and a preparation method and application thereof, and belongs to the technical field of medicine synthesis. The key point of the technical scheme is as follows: the triazole methyl ester linked spiro compound with antibacterial activity has the following structure: (the formula is shown in the description). The invention also discloses a preparation method of the triazole methyl ester linked spiro compound with antibacterial activity. The reaction process is simple and practical in operation, theraw materials are cheap and easily available, the reaction efficiency is high, the repeatability is high, and a remarkable inhibition effect on escherichia coli is achieved.

ACYLGUANIDINE DERIVATIVE

An object of the present invention is to provide an excellent agent for treating or preventing dementia, schizophrenia based on a serotonin 5-HT5A receptor modulating action. It was confirmed that acylguanidine derivatives, which has the charac