N-((5-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)-1-methyl-2,3-dihydro-1H-inden-1-yl)methyl)methanesulfonamide

Base Information

Chemical Name:N-((5-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)-1-methyl-2,3-dihydro-1H-inden-1-yl)methyl)methanesulfonamide
CAS No.:1132936-49-2
Molecular Formula:C₂₇H₃₃N₃O₅S
Molecular Weight:511.642
Hs Code.:

Synonyms:N-((5-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)-1-methyl-2,3-dihydro-1H-inden-1-yl)methyl)methanesulfonamide

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Chemical Property of N-((5-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)-1-methyl-2,3-dihydro-1H-inden-1-yl)methyl)methanesulfonamide

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Technology Process of N-((5-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)-1-methyl-2,3-dihydro-1H-inden-1-yl)methyl)methanesulfonamide

There total 4 articles about N-((5-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)-1-methyl-2,3-dihydro-1H-inden-1-yl)methyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₃₁N₃O₃*ClH

: 124-63-0
methanesulfonyl chloride

: 1132936-49-2
N-((5-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)-1-methyl-2,3-dihydro-1H-inden-1-yl)methyl)methanesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 1132944-07-0
tert-butyl (1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-yl)methylcarbamate

: 124-63-0
methanesulfonyl chloride

: 1132936-49-2
N-((5-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)-1-methyl-2,3-dihydro-1H-inden-1-yl)methyl)methanesulfonamide

Guidance literature:: tert-butyl (1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-yl)methylcarbamate; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In ethanol; toluene; at 100 ℃; for 1h; Microwave irradiation;

With hydrogenchloride; In 1,4-dioxane; at 25 ℃; for 18h;

methanesulfonyl chloride; In pyridine; at 25 ℃; for 1h;
DOI:10.1016/j.bmcl.2013.04.057

Reference yield:

: 34598-49-7
5-Bromo-1-indanone

: 1132936-49-2
N-((5-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)-1-methyl-2,3-dihydro-1H-inden-1-yl)methyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; 1,3 dithiane / tetrahydrofuran / -30 - 0 °C

1.2: 1 h / Reflux

2.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 25 °C

2.2: 3 h / Reflux

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / toluene; ethanol / 1 h / 100 °C / Microwave irradiation

3.2: 18 h / 25 °C

3.3: 1 h / 25 °C

With 1,3 dithiane; n-butyllithium; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; toluene;
DOI:10.1016/j.bmcl.2013.04.057