(S)-4-chloro-6-<<1,4-bis(benzyloxy)but-2-oxy>amino>-2,5-diformamidopyrimidine

Base Information

Chemical Name:(S)-4-chloro-6-<<1,4-bis(benzyloxy)but-2-oxy>amino>-2,5-diformamidopyrimidine
CAS No.:114778-36-8
Molecular Formula:C₂₄H₂₆ClN₅O₅
Molecular Weight:499.954
Hs Code.:

Synonyms:(S)-4-chloro-6-<<1,4-bis(benzyloxy)but-2-oxy>amino>-2,5-diformamidopyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4-chloro-6-<<1,4-bis(benzyloxy)but-2-oxy>amino>-2,5-diformamidopyrimidine

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Technology Process of (S)-4-chloro-6-<<1,4-bis(benzyloxy)but-2-oxy>amino>-2,5-diformamidopyrimidine

There total 4 articles about (S)-4-chloro-6-<<1,4-bis(benzyloxy)but-2-oxy>amino>-2,5-diformamidopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 116477-30-6
4,6-dichloro-2,5-diformamido-pyrimidine

: 114778-35-7
(S)-1,4-bis(benzyloxy)but-2-oxyamine

: 114778-36-8
(S)-4-chloro-6-<<1,4-bis(benzyloxy)but-2-oxy>amino>-2,5-diformamidopyrimidine

Guidance literature:: With triethylamine; In 1,4-dioxane; at 100 ℃; for 1.5h;
DOI:10.1021/jm00105a010

Reference yield:

: 100-39-0
benzyl bromide

: 114778-36-8
(S)-4-chloro-6-<<1,4-bis(benzyloxy)but-2-oxy>amino>-2,5-diformamidopyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) DMF, RT, 6 h, 2.) 20 deg C, 18 h

2: 88 percent / 2percent methanol. HCl / methanol / 7 h / 20 °C

3: 91 percent / Ph₃P, DEAD / tetrahydrofuran / 40 h / 20 °C

4: 76 percent / methylhydrazine / CH₂Cl₂ / 1 h / 20 °C

5: 71 percent / Et₃N / dioxane / 1.5 h / 100 °C

With hydrogenchloride; sodium hydride; triethylamine; triphenylphosphine; methylhydrazine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm00105a010

Reference yield:

: 114818-98-3
(R)-1,4-bis(benzyloxy)butan-2-ol

: 114778-36-8
(S)-4-chloro-6-<<1,4-bis(benzyloxy)but-2-oxy>amino>-2,5-diformamidopyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / Ph₃P, DEAD / tetrahydrofuran / 40 h / 20 °C

2: 76 percent / methylhydrazine / CH₂Cl₂ / 1 h / 20 °C

3: 71 percent / Et₃N / dioxane / 1.5 h / 100 °C

With triethylamine; triphenylphosphine; methylhydrazine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/jm00105a010