2-iodo-3-phenylquinoline

Base Information

• Chemical Name: 2-iodo-3-phenylquinoline
• CAS No.: 1253101-33-5
• Molecular Formula: C₁₅H₁₀IN
• Molecular Weight: 331.156
• Mol file: 1253101-33-5.mol

Synonyms:2-iodo-3-phenylquinoline

Chemical Property of 2-iodo-3-phenylquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-iodo-3-phenylquinoline

There total 1 articles about 2-iodo-3-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-phenylethynyl)phenyl isocyanide (247222-84-0) → 2-iodo-3-phenylquinoline (1253101-33-5)

Guidance literature:

With iodoform; triethylamine; at 20 ℃; for 4h;

DOI:10.1246/bcsj.20100044

Reference yield: 93.0%

2-iodo-3-phenylquinoline (1253101-33-5) + 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetonitrile (138500-86-4) → 2-(4-(3-phenylquinolin-2-yl)phenyl)acetonitrile (1357158-82-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; at 100 ℃; for 18h; Inert atmosphere;

DOI:10.1021/jm201394e

Reference yield:

2-iodo-3-phenylquinoline (1253101-33-5) → 1-(4-(3-phenylquinolin-2-yl)phenyl)cyclobutanecarbonitrile (1357158-83-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 18 h / 100 °C / Inert atmosphere

2: tetrabutylammomium bromide; potassium hydroxide / water; toluene / 70 - 100 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; potassium carbonate; potassium hydroxide; In 1,4-dioxane; water; toluene; 1: Suzuki coupling;

DOI:10.1021/jm201394e

upstream raw materials:

2-(2-phenylethynyl)phenyl isocyanide

Downstream raw materials:

1-(4-(3-phenylquinolin-2-yl)phenyl)cyclobutanecarbonitrile

1-(4-(3-phenylquinolin-2-yl)phenyl)cyclobutanecarboxylic acid

2-(4-(1-isocyanatocyclobutyl)phenyl)-3-phenylquinoline

1-(4-(3-phenylquinolin-2-yl)phenyl)cyclobutanamine

Refernces