Technology Process of 1-(4-(3-phenylquinolin-2-yl)phenyl)cyclobutanecarboxylic acid
There total 4 articles about 1-(4-(3-phenylquinolin-2-yl)phenyl)cyclobutanecarboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
diethylene glycol;
at 245 ℃;
for 1.25h;
Inert atmosphere;
DOI:10.1021/jm201394e
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrabutylammomium bromide; potassium hydroxide / water; toluene / 70 - 100 °C / Inert atmosphere
2: potassium hydroxide / diethylene glycol / 1.25 h / 245 °C / Inert atmosphere
With
tetrabutylammomium bromide; potassium hydroxide;
In
water; toluene; diethylene glycol;
DOI:10.1021/jm201394e
- Guidance literature:
-
Multi-step reaction with 3 steps
1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 1,4-dioxane / 18 h / 100 °C / Inert atmosphere
2: tetrabutylammomium bromide; potassium hydroxide / water; toluene / 70 - 100 °C / Inert atmosphere
3: potassium hydroxide / diethylene glycol / 1.25 h / 245 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); tetrabutylammomium bromide; potassium carbonate; potassium hydroxide;
In
1,4-dioxane; water; toluene; diethylene glycol;
1: Suzuki coupling;
DOI:10.1021/jm201394e
