methyl 2-[N-(benzyloxycarbonyl)amino]-4-(1-ethoxycarbonylpropyltetrazol-5-yl)butyrate

Base Information

Chemical Name:methyl 2-[N-(benzyloxycarbonyl)amino]-4-(1-ethoxycarbonylpropyltetrazol-5-yl)butyrate
CAS No.:277758-36-8
Molecular Formula:C₂₀H₂₇N₅O₆
Molecular Weight:433.464
Hs Code.:

Synonyms:methyl 2-[N-(benzyloxycarbonyl)amino]-4-(1-ethoxycarbonylpropyltetrazol-5-yl)butyrate

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Chemical Property of methyl 2-[N-(benzyloxycarbonyl)amino]-4-(1-ethoxycarbonylpropyltetrazol-5-yl)butyrate

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Technology Process of methyl 2-[N-(benzyloxycarbonyl)amino]-4-(1-ethoxycarbonylpropyltetrazol-5-yl)butyrate

There total 1 articles about methyl 2-[N-(benzyloxycarbonyl)amino]-4-(1-ethoxycarbonylpropyltetrazol-5-yl)butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 277758-35-7
ethyl 4-[α-methyl N-(benzyloxycarbonyl)-L-γ-glutamyl]aminobutyrate

: 277758-36-8
methyl 2-[N-(benzyloxycarbonyl)amino]-4-(1-ethoxycarbonylpropyltetrazol-5-yl)butyrate

Guidance literature:: ethyl 4-[α-methyl N-(benzyloxycarbonyl)-L-γ-glutamyl]aminobutyrate; With quinoline; phosphorus pentachloride; In chloroform; for 0.416667h;

With tris-(2-chloro-ethyl)-amine; In chloroform; benzene; at 20 ℃; for 3.5h; Further stages.;
DOI:10.1021/jm991119p

Reference yield:

: 277758-36-8
methyl 2-[N-(benzyloxycarbonyl)amino]-4-(1-ethoxycarbonylpropyltetrazol-5-yl)butyrate

: 277758-29-9
methyl (2S)-2-[4-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzamido]-4-(1-ethoxycarbonylpropyltetrazol-5-yl)butyrate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h

2: 61 percent / DEPC; Et₃N / dimethylformamide / 20 °C

With hydrogen; triethylamine; diethyl dicarbonate; 10percent Pd/C; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm991119p

Reference yield:

: 277758-36-8
methyl 2-[N-(benzyloxycarbonyl)amino]-4-(1-ethoxycarbonylpropyltetrazol-5-yl)butyrate

: 4-[1-(3-carboxy-propyl)-1H-tetrazol-5-yl]-2-{4-[(2-methyl-4-oxo-4,6,7,8-tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)-prop-2-ynyl-amino]-benzoylamino}-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h

2: 61 percent / DEPC; Et₃N / dimethylformamide / 20 °C

3: 85 percent / aq. NaOH / methanol / 20 °C

With sodium hydroxide; hydrogen; triethylamine; diethyl dicarbonate; 10percent Pd/C; In methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm991119p