methyl (2S)-2-[4-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzamido]-4-(1-ethoxycarbonylpropyltetrazol-5-yl)butyrate

Base Information

Chemical Name:methyl (2S)-2-[4-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzamido]-4-(1-ethoxycarbonylpropyltetrazol-5-yl)butyrate
CAS No.:277758-29-9
Molecular Formula:C₃₄H₃₈N₈O₆
Molecular Weight:654.726
Hs Code.:

methyl (2S)-2-[4-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzamido]-4-(1-ethoxycarbonylpropyltetrazol-5-yl)butyrate

Synonyms:methyl (2S)-2-[4-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzamido]-4-(1-ethoxycarbonylpropyltetrazol-5-yl)butyrate

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Chemical Property of methyl (2S)-2-[4-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzamido]-4-(1-ethoxycarbonylpropyltetrazol-5-yl)butyrate

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Technology Process of methyl (2S)-2-[4-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzamido]-4-(1-ethoxycarbonylpropyltetrazol-5-yl)butyrate

There total 3 articles about methyl (2S)-2-[4-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzamido]-4-(1-ethoxycarbonylpropyltetrazol-5-yl)butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 174487-71-9
4-{N-[(6R/6S)-2-Methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoic acid

: 277758-22-2
methyl 2-amino-4-(1-ethoxycarbonylpropyltetrazol-5-yl)butyrate

: 277758-29-9
methyl (2S)-2-[4-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzamido]-4-(1-ethoxycarbonylpropyltetrazol-5-yl)butyrate

Guidance literature:: With triethylamine; diethyl dicarbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm991119p

Reference yield:

: 277758-36-8
methyl 2-[N-(benzyloxycarbonyl)amino]-4-(1-ethoxycarbonylpropyltetrazol-5-yl)butyrate

: 277758-29-9
methyl (2S)-2-[4-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzamido]-4-(1-ethoxycarbonylpropyltetrazol-5-yl)butyrate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h

2: 61 percent / DEPC; Et₃N / dimethylformamide / 20 °C

With hydrogen; triethylamine; diethyl dicarbonate; 10percent Pd/C; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm991119p

Reference yield:

: 157701-04-7
N-(4-{N-[(6RS)-2-Methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoyl)-L-glutamic acid

: 277758-29-9
methyl (2S)-2-[4-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzamido]-4-(1-ethoxycarbonylpropyltetrazol-5-yl)butyrate

Guidance literature:: Multi-step reaction with 2 steps

1: 0.913 g / carboxypeptidase G₂; aq. tris-HCl buffer; ZnCl₂ / 69 h / 37 °C / pH 7.3

2: 61 percent / DEPC; Et₃N / dimethylformamide / 20 °C

With Tris-HCl buffer; carboxypeptidase G₂; triethylamine; diethyl dicarbonate; zinc(II) chloride; In N,N-dimethyl-formamide;
DOI:10.1021/jm991119p