5-(3,4,5-trimethoxyphenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

Base Information

Chemical Name:5-(3,4,5-trimethoxyphenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one
CAS No.:1229584-04-6
Molecular Formula:C₂₂H₃₀N₂O₅Si
Molecular Weight:430.576
Hs Code.:

Synonyms:5-(3,4,5-trimethoxyphenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

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Chemical Property of 5-(3,4,5-trimethoxyphenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

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Technology Process of 5-(3,4,5-trimethoxyphenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

There total 5 articles about 5-(3,4,5-trimethoxyphenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1229584-03-5
5-bromo-1-{[2-(trimethylsilyl)ethoxy]methyl}-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 1229584-04-6
5-(3,4,5-trimethoxyphenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In acetonitrile; at 80 ℃; for 2h; Inert atmosphere;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1229584-04-6
5-(3,4,5-trimethoxyphenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.25 h / 0 °C

1.2: 1.25 h

2.1: bromine; water / tert-butyl alcohol / 21.5 h / 20 °C

3.1: zinc; acetic acid / 2 h / 20 °C

4.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 2 h / 80 °C / Inert atmosphere

With water; bromine; sodium hydride; sodium carbonate; acetic acid; zinc; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; acetonitrile; mineral oil; tert-butyl alcohol;

Reference yield:

: 271-63-6
7-Azaindole

: 1229584-04-6
5-(3,4,5-trimethoxyphenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.25 h / 0 °C

1.2: 1.25 h

2.1: bromine; water / tert-butyl alcohol / 21.5 h / 20 °C

3.1: zinc; acetic acid / 2 h / 20 °C

4.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 2 h / 80 °C / Inert atmosphere

With water; bromine; sodium hydride; sodium carbonate; acetic acid; zinc; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; acetonitrile; mineral oil; tert-butyl alcohol;