3-[3-(5-hydroxypyrimidin-2-yl)benzyl]-5-methyl-3H-oxazolo-[4,5-b]pyridin-2-one

Base Information

• Chemical Name: 3-[3-(5-hydroxypyrimidin-2-yl)benzyl]-5-methyl-3H-oxazolo-[4,5-b]pyridin-2-one
• CAS No.: 1092568-93-8
• Molecular Formula: C₁₈H₁₄N₄O₃
• Molecular Weight: 334.334

Synonyms:3-[3-(5-hydroxypyrimidin-2-yl)benzyl]-5-methyl-3H-oxazolo-[4,5-b]pyridin-2-one

Chemical Property of 3-[3-(5-hydroxypyrimidin-2-yl)benzyl]-5-methyl-3H-oxazolo-[4,5-b]pyridin-2-one

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Technology Process of 3-[3-(5-hydroxypyrimidin-2-yl)benzyl]-5-methyl-3H-oxazolo-[4,5-b]pyridin-2-one

There total 1 articles about 3-[3-(5-hydroxypyrimidin-2-yl)benzyl]-5-methyl-3H-oxazolo-[4,5-b]pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3-((5-methyl-2-oxooxazolo[4,5-b]pyridin-3(2H)-yl)-methyl)phenyl)pyrimidin-5-yl-5-boronic acid (1092568-92-7) → 3-[3-(5-hydroxypyrimidin-2-yl)benzyl]-5-methyl-3H-oxazolo-[4,5-b]pyridin-2-one (1092568-93-8)

Guidance literature:

With sodium perborate; In tetrahydrofuran; water; at 20 ℃; for 2h; Cooling with ice;

Reference yield:

3-[3-(5-hydroxypyrimidin-2-yl)benzyl]-5-methyl-3H-oxazolo-[4,5-b]pyridin-2-one (1092568-93-8) + 3-monochloro-1,2-propanediol (96-24-2) → 3-{3-[5-(2,3-dihydroxypropoxy)pyrimidin-2-yl]benzyl}-5-methyl-3H-oxazolo[4,5-b]pyridin-2-one (1092568-07-4)

Guidance literature:

With caesium carbonate; In acetone; at 20 ℃; for 16h;

Reference yield:

2-(N,N-dimethylamino)ethanol (108-01-0) + 3-[3-(5-hydroxypyrimidin-2-yl)benzyl]-5-methyl-3H-oxazolo-[4,5-b]pyridin-2-one (1092568-93-8) → 3-{3-[5-(2-dimethylaminoethoxy)pyrimidin-2-yl]benzyl}-5-methyl-3H-oxazolo[4,5-b]pyridin-2-one (1092567-96-8)

Guidance literature:

With di-tert-butyl-diazodicarboxylate; In N,N-dimethyl-formamide; at 20 ℃; for 54h;

upstream raw materials:

2-(3-((5-methyl-2-oxooxazolo[4,5-b]pyridin-3(2H)-yl)-methyl)phenyl)pyrimidin-5-yl-5-boronic acid

Downstream raw materials:

3-{3-[5-(2,3-dihydroxypropoxy)pyrimidin-2-yl]benzyl}-5-methyl-3H-oxazolo[4,5-b]pyridin-2-one

3-{3-[5-(2-dimethylaminoethoxy)pyrimidin-2-yl]benzyl}-5-methyl-3H-oxazolo[4,5-b]pyridin-2-one

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