oxetan-3-yl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate

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Chemical Name:oxetan-3-yl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate
CAS No.:1374344-63-4
Molecular Formula:C₂₁H₁₈F₂N₈O₃
Molecular Weight:468.423
Hs Code.:

Synonyms:oxetan-3-yl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate

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Chemical Property of oxetan-3-yl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate

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Technology Process of oxetan-3-yl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate

There total 7 articles about oxetan-3-yl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 7748-36-9
oxetan-3-ol

: 32315-10-9
bis(trichloromethyl) carbonate

: 1374344-83-8
2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidine-4,5,6-triamine

: 1374344-63-4
oxetan-3-yl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate

Guidance literature:: oxetan-3-ol; bis(trichloromethyl) carbonate; With pyridine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidine-4,5,6-triamine; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: 1374344-81-6
2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-5-nitropyrimidine-4,6-diamine

: 1374344-63-4
oxetan-3-yl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen; pyridine

2.1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With pyridine; palladium 10% on activated carbon; hydrogen; In dichloromethane;

Reference yield:

: 1048340-35-7
3,5-difluoropyridine-2-carbonyl chloride

: 1374344-63-4
oxetan-3-yl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: sodium chloride; water / dimethyl sulfoxide / 0.5 h / 150 °C / Microwave irradiation

3.1: hydrazine hydrate; dmap / pyridine / 0.5 h / Reflux

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C

4.2: 1 h / 80 °C

5.1: palladium 10% on activated carbon; hydrogen; pyridine

6.1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

6.2: 20 °C / Inert atmosphere

With pyridine; dmap; palladium 10% on activated carbon; water; hydrogen; sodium hydride; hydrazine hydrate; sodium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; pyridine; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;