2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidine-4,5,6-triamine

Base Information

Chemical Name:2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidine-4,5,6-triamine
CAS No.:1374344-83-8
Molecular Formula:C₁₇H₁₄F₂N₈
Molecular Weight:368.349
Hs Code.:

Synonyms:2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidine-4,5,6-triamine

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Chemical Property of 2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidine-4,5,6-triamine

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Technology Process of 2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidine-4,5,6-triamine

There total 7 articles about 2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidine-4,5,6-triamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1374344-81-6
2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-5-nitropyrimidine-4,6-diamine

: 1374344-83-8
2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidine-4,5,6-triamine

Guidance literature:: With pyridine; palladium 10% on activated carbon; hydrogen;

Reference yield:

: 1048340-35-7
3,5-difluoropyridine-2-carbonyl chloride

: 1374344-83-8
2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidine-4,5,6-triamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: sodium chloride; water / dimethyl sulfoxide / 0.5 h / 150 °C / Microwave irradiation

3.1: hydrazine hydrate; dmap / pyridine / 0.5 h / Reflux

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C

4.2: 1 h / 80 °C

5.1: palladium 10% on activated carbon; hydrogen; pyridine

With pyridine; dmap; palladium 10% on activated carbon; water; hydrogen; sodium hydride; hydrazine hydrate; sodium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; pyridine; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1361570-31-1
methyl 3-(3,5-difluoropyridin-2-yl)-2-(2-fluorophenyl)-3-oxopropanoate

: 1374344-83-8
2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidine-4,5,6-triamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium chloride; water / dimethyl sulfoxide / 0.5 h / 150 °C / Microwave irradiation

2.1: hydrazine hydrate; dmap / pyridine / 0.5 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C

3.2: 1 h / 80 °C

4.1: palladium 10% on activated carbon; hydrogen; pyridine

With pyridine; dmap; palladium 10% on activated carbon; water; hydrogen; sodium hydride; hydrazine hydrate; sodium chloride; In pyridine; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;