N-((S)-3-{4-[3-(2-cyclopentyl-6-methoxypyridin-4-yl)[1,2,4]oxadiazol-5-yl]-2-ethyl-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide

Base Information

Chemical Name:N-((S)-3-{4-[3-(2-cyclopentyl-6-methoxypyridin-4-yl)[1,2,4]oxadiazol-5-yl]-2-ethyl-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide
CAS No.:1262414-31-2
Molecular Formula:C₂₇H₃₄N₄O₆
Molecular Weight:510.59
Hs Code.:

Synonyms:N-((S)-3-{4-[3-(2-cyclopentyl-6-methoxypyridin-4-yl)[1,2,4]oxadiazol-5-yl]-2-ethyl-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide

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Chemical Property of N-((S)-3-{4-[3-(2-cyclopentyl-6-methoxypyridin-4-yl)[1,2,4]oxadiazol-5-yl]-2-ethyl-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide

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Technology Process of N-((S)-3-{4-[3-(2-cyclopentyl-6-methoxypyridin-4-yl)[1,2,4]oxadiazol-5-yl]-2-ethyl-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide

There total 13 articles about N-((S)-3-{4-[3-(2-cyclopentyl-6-methoxypyridin-4-yl)[1,2,4]oxadiazol-5-yl]-2-ethyl-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-14-1
glycolic Acid

: 1262414-33-4
(2S)-1-amino-3-{4-[3-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-5-yl]-2-ethyl-6-methyl-phenoxy}-propan-2-ol

: 1262414-31-2
N-((S)-3-{4-[3-(2-cyclopentyl-6-methoxypyridin-4-yl)[1,2,4]oxadiazol-5-yl]-2-ethyl-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 944327-07-5
4-benzyloxy-3-ethyl-5-methylbenzaldehyde

: 1262414-31-2
N-((S)-3-{4-[3-(2-cyclopentyl-6-methoxypyridin-4-yl)[1,2,4]oxadiazol-5-yl]-2-ethyl-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate dihydrate / water; tert-butyl alcohol / 30 °C

2: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1 h / 20 °C

3: 1,4-dioxane / 48 h / 115 °C

4: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 24 h / 20 °C / 750.08 Torr

5: sodium hydroxide / isopropyl alcohol; water / 72 h / 20 °C

6: ammonia / methanol / 24 h / 65 °C

7: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; ammonia; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; isopropyl alcohol; tert-butyl alcohol;

Reference yield:

: 944327-05-3
4-benzyloxy-3-ethyl-5-methylbenzoic acid

: 1262414-31-2
N-((S)-3-{4-[3-(2-cyclopentyl-6-methoxypyridin-4-yl)[1,2,4]oxadiazol-5-yl]-2-ethyl-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1 h / 20 °C

2: 1,4-dioxane / 48 h / 115 °C

3: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 24 h / 20 °C / 750.08 Torr

4: sodium hydroxide / isopropyl alcohol; water / 72 h / 20 °C

5: ammonia / methanol / 24 h / 65 °C

6: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1 h / 20 °C

With ammonia; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; isopropyl alcohol;