2-[2-(2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid methyl ester

Base Information

Chemical Name:2-[2-(2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid methyl ester
CAS No.:168965-60-4
Molecular Formula:C₂₀H₃₂N₂O₅
Molecular Weight:380.484
Hs Code.:

Synonyms:2-[2-(2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid methyl ester

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Chemical Property of 2-[2-(2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid methyl ester

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Technology Process of 2-[2-(2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid methyl ester

There total 10 articles about 2-[2-(2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070-19-5
N-(tert-butyloxycarbonyl) azide

: 168965-60-4
2-[2-(2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / NaHCO₃ / dioxane; H₂O / 64 h / 40 - 50 °C

2: 96 percent / LiBH₄ / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) RT, 3 h

3: 96 percent / H₂, H₂O / 10percent Pd/C / ethyl acetate / 2 h / 760 Torr / Ambient temperature

4: 2.) NaBH₃CN, 3.) H₂ / 3.) Pd/C

With lithium borohydride; water; hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate;
DOI:10.1021/ja953578v

Reference yield:

: 42721-25-5
ethyl 2-(acetylamino)-3-(2-nitrophenyl)propanoate

: 168965-60-4
2-[2-(2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: HCl / ethanol / 48 h / Heating

2: 83 percent / NaHCO₃ / dioxane; H₂O / 64 h / 40 - 50 °C

3: 96 percent / LiBH₄ / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) RT, 3 h

4: 96 percent / H₂, H₂O / 10percent Pd/C / ethyl acetate / 2 h / 760 Torr / Ambient temperature

5: 2.) NaBH₃CN, 3.) H₂ / 3.) Pd/C

With hydrogenchloride; lithium borohydride; water; hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; water; ethyl acetate;
DOI:10.1021/ja953578v

Reference yield:

: 91176-91-9
N-Acetyl-(o-nitrophenyl)-DL-alanin

: 168965-60-4
2-[2-(2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: SOCl₂ / 1.) RT, 1 h, 2.) 60 deg C, 3 h

2: HCl / ethanol / 48 h / Heating

3: 83 percent / NaHCO₃ / dioxane; H₂O / 64 h / 40 - 50 °C

4: 96 percent / LiBH₄ / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) RT, 3 h

5: 96 percent / H₂, H₂O / 10percent Pd/C / ethyl acetate / 2 h / 760 Torr / Ambient temperature

6: 2.) NaBH₃CN, 3.) H₂ / 3.) Pd/C

With hydrogenchloride; lithium borohydride; thionyl chloride; water; hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; water; ethyl acetate;
DOI:10.1021/ja953578v