Technology Process of 2-[2-(2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid
There total 11 articles about 2-[2-(2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 83 percent / NaHCO3 / dioxane; H2O / 64 h / 40 - 50 °C
2: 96 percent / LiBH4 / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) RT, 3 h
3: 96 percent / H2, H2O / 10percent Pd/C / ethyl acetate / 2 h / 760 Torr / Ambient temperature
4: 2.) NaBH3CN, 3.) H2 / 3.) Pd/C
5: 2 N aq. KOH / methanol / 24 h / Ambient temperature
With
potassium hydroxide; lithium borohydride; water; hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate;
DOI:10.1021/ja953578v
- Guidance literature:
-
Multi-step reaction with 7 steps
1: SOCl2 / 1.) RT, 1 h, 2.) 60 deg C, 3 h
2: HCl / ethanol / 48 h / Heating
3: 83 percent / NaHCO3 / dioxane; H2O / 64 h / 40 - 50 °C
4: 96 percent / LiBH4 / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) RT, 3 h
5: 96 percent / H2, H2O / 10percent Pd/C / ethyl acetate / 2 h / 760 Torr / Ambient temperature
6: 2.) NaBH3CN, 3.) H2 / 3.) Pd/C
7: 2 N aq. KOH / methanol / 24 h / Ambient temperature
With
hydrogenchloride; potassium hydroxide; lithium borohydride; thionyl chloride; water; hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; ethyl acetate;
DOI:10.1021/ja953578v
- Guidance literature:
-
Multi-step reaction with 9 steps
1: aq. NaOH / 1.17 h / Heating
2: H2O / 3 h / 100 °C
3: SOCl2 / 1.) RT, 1 h, 2.) 60 deg C, 3 h
4: HCl / ethanol / 48 h / Heating
5: 83 percent / NaHCO3 / dioxane; H2O / 64 h / 40 - 50 °C
6: 96 percent / LiBH4 / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) RT, 3 h
7: 96 percent / H2, H2O / 10percent Pd/C / ethyl acetate / 2 h / 760 Torr / Ambient temperature
8: 2.) NaBH3CN, 3.) H2 / 3.) Pd/C
9: 2 N aq. KOH / methanol / 24 h / Ambient temperature
With
hydrogenchloride; potassium hydroxide; sodium hydroxide; lithium borohydride; thionyl chloride; water; hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; ethyl acetate;
DOI:10.1021/ja953578v
