4-(5-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-1,2,4-triazol-1-yl)methyl)thiazol-2-yl)morpholine

Base Information

Chemical Name:4-(5-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-1,2,4-triazol-1-yl)methyl)thiazol-2-yl)morpholine
CAS No.:1570494-64-2
Molecular Formula:C₂₀H₁₈F₃N₇O₃S
Molecular Weight:493.469
Hs Code.:

Synonyms:4-(5-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-1,2,4-triazol-1-yl)methyl)thiazol-2-yl)morpholine

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Chemical Property of 4-(5-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-1,2,4-triazol-1-yl)methyl)thiazol-2-yl)morpholine

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Technology Process of 4-(5-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-1,2,4-triazol-1-yl)methyl)thiazol-2-yl)morpholine

There total 7 articles about 4-(5-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-1,2,4-triazol-1-yl)methyl)thiazol-2-yl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 110-91-8,99108-56-2
morpholine

: 1570494-62-0
5-(1-((2-chlorothiazol-5-yl)methyl)-5-methyl-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

: 1570494-64-2
4-(5-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-1,2,4-triazol-1-yl)methyl)thiazol-2-yl)morpholine

Guidance literature:: In dimethyl sulfoxide; at 140 ℃;

Reference yield:

: C₁₂H₁₀F₃N₅O₃

: 1570494-64-2
4-(5-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-1,2,4-triazol-1-yl)methyl)thiazol-2-yl)morpholine

Guidance literature:: Multi-step reaction with 3 steps

1: ethylene glycol / 3 h / 180 °C

2: potassium carbonate; sodium iodide / tetrahydrofuran / 72 h / 20 °C

3: dimethyl sulfoxide / 140 °C

With potassium carbonate; sodium iodide; In tetrahydrofuran; ethylene glycol; dimethyl sulfoxide;

Reference yield:

: 1570493-58-1
5-(5-methyl-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

: 1570494-64-2
4-(5-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-1,2,4-triazol-1-yl)methyl)thiazol-2-yl)morpholine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; sodium iodide / tetrahydrofuran / 72 h / 20 °C

2: dimethyl sulfoxide / 140 °C

With potassium carbonate; sodium iodide; In tetrahydrofuran; dimethyl sulfoxide;