ethyl 3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole-5-carboxylate

Base Information

• Chemical Name: ethyl 3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole-5-carboxylate
• CAS No.: 1258269-03-2
• Molecular Formula: C₁₂H₉F₃N₂O₄
• Molecular Weight: 302.21
• Mol file: 1258269-03-2.mol

Synonyms:ethyl 3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole-5-carboxylate

Chemical Property of ethyl 3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole-5-carboxylate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole-5-carboxylate

There total 2 articles about ethyl 3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-(trifluoromethoxy)benzamidoxime + Ethyl oxalyl chloride (4755-77-5) → ethyl 3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole-5-carboxylate (1258269-03-2)

Guidance literature:

With pyridine; In chloroform; at 0 ℃; for 3h;

DOI:10.1038/s41591-018-0052-4

Reference yield:

ethyl 3-bromo-1,2,4-oxadiazole-5-carboxylate (121562-09-2) + 4-trifluoromethoxyphenylboronic acid (139301-27-2) → ethyl 3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole-5-carboxylate (1258269-03-2)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In isopropyl alcohol; Reflux;

DOI:10.1016/j.bmcl.2010.08.121

Reference yield: 92.0%

ethyl 3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole-5-carboxylate (1258269-03-2) → 3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole-5-carbohydrazide (883028-82-8)

Guidance literature:

With hydrazine; In ethanol; water; at 20 ℃; for 16h;

DOI:10.1038/s41591-018-0052-4

upstream raw materials:

ethyl 3-bromo-1,2,4-oxadiazole-5-carboxylate

4-trifluoromethoxyphenylboronic acid

Ethyl oxalyl chloride

Downstream raw materials:

C₁₀H₅F₃N₂O₄

benzyl 4-(4-((2-methyl-5-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-2H-1,2,4-triazol-3-yl)methyl)pyridin-2-yl)piperazine-1-carboxylate

4-(4-((1-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-1,2,4-triazol-5-yl)methyl)pyridin-2-yl)piperazin-1-ium formate

sodium 3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole-5-carboxylate