Technology Process of N-(6-(hydroxyamino)-6-oxohexyl)-3-(4-hydroxyphenyl)-5-phenyl-1H-pyrrole-2-carboxamide
There total 17 articles about N-(6-(hydroxyamino)-6-oxohexyl)-3-(4-hydroxyphenyl)-5-phenyl-1H-pyrrole-2-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 6-[3-(4-hydroxyphenyl)-5-phenyl-1H-pyrrole-2-carboxamido] hexanoate;
With
phenolphthalein; hydroxylamine hydrochloride; sodium methylate;
In
methanol;
for 26h;
Inert atmosphere;
With
acetic acid;
In
methanol; water;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine; silver(I) acetate / 20 °C
1.2: 48 h / Inert atmosphere; Reflux
2.1: sodium hydroxide / 1,2-dimethoxyethane; ethanol; water
3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 98 h / 0 - 20 °C
4.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 20 °C
5.1: hydroxylamine hydrochloride; sodium methylate; phenolphthalein / methanol / 26 h / Inert atmosphere
With
4-methyl-morpholine; phenolphthalein; hydroxylamine hydrochloride; hydrogen; sodium methylate; silver(I) acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide;
palladium 10% on activated carbon;
In
methanol; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine; silver(I) acetate / 20 °C
1.2: 48 h / Inert atmosphere; Reflux
2.1: sodium hydroxide / 1,2-dimethoxyethane; ethanol; water
3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 98 h / 0 - 20 °C
4.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 20 °C
5.1: hydroxylamine hydrochloride; sodium methylate; phenolphthalein / methanol / 26 h / Inert atmosphere
With
4-methyl-morpholine; phenolphthalein; hydroxylamine hydrochloride; hydrogen; sodium methylate; silver(I) acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide;
palladium 10% on activated carbon;
In
methanol; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;
![methyl 6-[3-(4-hydroxyphenyl)-5-phenyl-1H-pyrrole-2-carboxamido] hexanoate](/Databaselist/images/loading.webp)
