4,6-dichloro-3-((3-(4-hydroxyphenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylic acid

Base Information

Chemical Name:4,6-dichloro-3-((3-(4-hydroxyphenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylic acid
CAS No.:1335466-04-0
Molecular Formula:C₁₉H₁₃Cl₂N₃O₅
Molecular Weight:434.235
Hs Code.:

Synonyms:4,6-dichloro-3-((3-(4-hydroxyphenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylic acid

Suppliers and Price of 4,6-dichloro-3-((3-(4-hydroxyphenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4,6-dichloro-3-((3-(4-hydroxyphenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4,6-dichloro-3-((3-(4-hydroxyphenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylic acid

There total 10 articles about 4,6-dichloro-3-((3-(4-hydroxyphenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1335465-98-9
3-((3-(4-(benzyloxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-4,6-dichloro-indole-2-carboxylic acid

: 1335466-04-0
4,6-dichloro-3-((3-(4-hydroxyphenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 60 ℃; under 750.075 Torr;
DOI:10.1002/jlcr.1901

Reference yield:

: 103855-01-2
ethyl 2-[2-(3,5-dichlorophenyl)hydrazinylidene]propanoate

: 1335466-04-0
4,6-dichloro-3-((3-(4-hydroxyphenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: polyphosphoric acid / 0.17 h / 70 - 130 °C

2.1: trichlorophosphate / 20 °C / Inert atmosphere

2.2: 8 h / Inert atmosphere; Reflux

3.1: triethylamine / dichloromethane / 0.17 h / Inert atmosphere

3.2: 0.25 h / Inert atmosphere

4.1: sodium tris(acetoxy)borohydride / dichloromethane / 1.5 h / Inert atmosphere

5.1: dichloromethane / 0 - 20 °C / Inert atmosphere

6.1: sodium ethanolate / ethanol / 1 h / 20 °C / Inert atmosphere

7.1: sodium hydroxide / tetrahydrofuran; water / 20 °C

8.1: palladium 10% on activated carbon; hydrogen / methanol / 60 °C / 750.08 Torr

With palladium 10% on activated carbon; hydrogen; sodium ethanolate; sodium tris(acetoxy)borohydride; triethylamine; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 1.1: Fischer indole synthesis / 2.2: Vilsmeier formylation;
DOI:10.1002/jlcr.1901

Reference yield:

: 6373-46-2
p-benzyloxyaniline

: 1335466-04-0
4,6-dichloro-3-((3-(4-hydroxyphenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C / Inert atmosphere

2: dichloromethane / 0 - 20 °C / Inert atmosphere

3: sodium ethanolate / ethanol / 1 h / 20 °C / Inert atmosphere

4: sodium hydroxide / tetrahydrofuran; water / 20 °C

5: palladium 10% on activated carbon; hydrogen / methanol / 60 °C / 750.08 Torr

With palladium 10% on activated carbon; hydrogen; sodium ethanolate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1002/jlcr.1901