ethyl 3-((3-(4-(benzyloxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-4,6-dichloro-indole-2-carboxylate

Base Information

Chemical Name:ethyl 3-((3-(4-(benzyloxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-4,6-dichloro-indole-2-carboxylate
CAS No.:1335465-94-5
Molecular Formula:C₂₈H₂₃Cl₂N₃O₅
Molecular Weight:552.414
Hs Code.:

Synonyms:ethyl 3-((3-(4-(benzyloxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-4,6-dichloro-indole-2-carboxylate

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Chemical Property of ethyl 3-((3-(4-(benzyloxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-4,6-dichloro-indole-2-carboxylate

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Technology Process of ethyl 3-((3-(4-(benzyloxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-4,6-dichloro-indole-2-carboxylate

There total 10 articles about ethyl 3-((3-(4-(benzyloxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-4,6-dichloro-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1335465-91-2
ethyl 3-((3-(4-(benzyloxy)phenyl)-1-(2-methoxy-2-oxoethyl)ureido) methyl)-4,6-dichloro-indole-2-carboxylate

: 1335465-94-5
ethyl 3-((3-(4-(benzyloxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-4,6-dichloro-indole-2-carboxylate

Guidance literature:: With sodium ethanolate; In ethanol; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1002/jlcr.1901

Reference yield:

: 103855-01-2
ethyl 2-[2-(3,5-dichlorophenyl)hydrazinylidene]propanoate

: 1335465-94-5
ethyl 3-((3-(4-(benzyloxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-4,6-dichloro-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: polyphosphoric acid / 0.17 h / 70 - 130 °C

2.1: trichlorophosphate / 20 °C / Inert atmosphere

2.2: 8 h / Inert atmosphere; Reflux

3.1: triethylamine / dichloromethane / 0.17 h / Inert atmosphere

3.2: 0.25 h / Inert atmosphere

4.1: sodium tris(acetoxy)borohydride / dichloromethane / 1.5 h / Inert atmosphere

5.1: dichloromethane / 0 - 20 °C / Inert atmosphere

6.1: sodium ethanolate / ethanol / 1 h / 20 °C / Inert atmosphere

With sodium ethanolate; sodium tris(acetoxy)borohydride; triethylamine; trichlorophosphate; In ethanol; dichloromethane; 1.1: Fischer indole synthesis / 2.2: Vilsmeier formylation;
DOI:10.1002/jlcr.1901

Reference yield:

: 6373-46-2
p-benzyloxyaniline

: 1335465-94-5
ethyl 3-((3-(4-(benzyloxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-4,6-dichloro-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C / Inert atmosphere

2: dichloromethane / 0 - 20 °C / Inert atmosphere

3: sodium ethanolate / ethanol / 1 h / 20 °C / Inert atmosphere

With sodium ethanolate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;
DOI:10.1002/jlcr.1901