5-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]tetrahydro-2H-1,2-oxazine

Base Information

Chemical Name:5-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]tetrahydro-2H-1,2-oxazine
CAS No.:1313705-37-1
Molecular Formula:C₁₆H₁₅F₂N₃O₂S
Molecular Weight:351.377
Hs Code.:

Synonyms:5-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]tetrahydro-2H-1,2-oxazine

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Chemical Property of 5-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]tetrahydro-2H-1,2-oxazine

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Technology Process of 5-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]tetrahydro-2H-1,2-oxazine

There total 11 articles about 5-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]tetrahydro-2H-1,2-oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1313705-36-0
ethyl 5-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]tetrahydro-2H-1,2-oxazine-2-carboxylate

: 1313705-37-1
5-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]tetrahydro-2H-1,2-oxazine

Guidance literature:: ethyl 5-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]tetrahydro-2H-1,2-oxazine-2-carboxylate; With water; potassium hydroxide; In ethanol; for 20h; Reflux;

With hydrogenchloride; In ethanol; water; at 70 ℃; for 0.333333h;

Reference yield:

: 207226-37-7,791521-82-9
1,3-difluoro-2-vinyl-benzene

: 1313705-37-1
5-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]tetrahydro-2H-1,2-oxazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydrogencarbonate / water; chlorobenzene / 1 h / 10 - 15 °C

2.1: tetrahydrofuran; toluene / -10 - -5 °C

3.1: bromine / dichloromethane / 5 - 33 °C

4.1: methanol / 1 h / 50 °C

5.1: water; potassium hydroxide / ethanol / 20 h / Reflux

5.2: 0.33 h / 70 °C

With water; bromine; potassium hydrogencarbonate; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; chlorobenzene; toluene;

Reference yield:

: 1173693-35-0
5-(2,6-difluorophenyl)-4,5-dihydro-N,N-dimethyl-3-isoxazolecarboxamide

: 1313705-37-1
5-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]tetrahydro-2H-1,2-oxazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran; toluene / -10 - -5 °C

2.1: bromine / dichloromethane / 5 - 33 °C

3.1: methanol / 1 h / 50 °C

4.1: water; potassium hydroxide / ethanol / 20 h / Reflux

4.2: 0.33 h / 70 °C

With water; bromine; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;