6-(4-fluorophenyl)-8-hydroxy-4-oxo-3,4-dihydroquinazoline-5-carbonitrile

Base Information

Chemical Name:6-(4-fluorophenyl)-8-hydroxy-4-oxo-3,4-dihydroquinazoline-5-carbonitrile
CAS No.:1616829-43-6
Molecular Formula:C₁₅H₈FN₃O₂
Molecular Weight:281.246
Hs Code.:

Synonyms:6-(4-fluorophenyl)-8-hydroxy-4-oxo-3,4-dihydroquinazoline-5-carbonitrile

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Chemical Property of 6-(4-fluorophenyl)-8-hydroxy-4-oxo-3,4-dihydroquinazoline-5-carbonitrile

Chemical Property:

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Technology Process of 6-(4-fluorophenyl)-8-hydroxy-4-oxo-3,4-dihydroquinazoline-5-carbonitrile

There total 5 articles about 6-(4-fluorophenyl)-8-hydroxy-4-oxo-3,4-dihydroquinazoline-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 1616829-44-7
6-(4-fluorophenyl)-8-methoxy-4-oxo-3-((2-(trimethylsilyl)ethoxy)methyl)-3,4-dihydroquinazoline-5-carbonitrile

: 1616829-43-6
6-(4-fluorophenyl)-8-hydroxy-4-oxo-3,4-dihydroquinazoline-5-carbonitrile

Guidance literature:: With boron tribromide; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1616829-35-6
6-bromo-8-methoxy-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one

: 1616829-43-6
6-(4-fluorophenyl)-8-hydroxy-4-oxo-3,4-dihydroquinazoline-5-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane / 3 h / 90 °C

2: bromine; silver(II) sulfate / acetic acid / 16 h / 20 °C

3: L-proline / N,N-dimethyl-formamide / 22 h / 100 - 120 °C

4: boron tribromide / dichloromethane / 16 h / 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; silver(II) sulfate; bromine; boron tribromide; potassium carbonate; L-proline; In 1,4-dioxane; dichloromethane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 1616829-36-7
6-(4-fluorophenyl)-8-methoxy-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one

: 1616829-43-6
6-(4-fluorophenyl)-8-hydroxy-4-oxo-3,4-dihydroquinazoline-5-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: bromine; silver(II) sulfate / acetic acid / 16 h / 20 °C

2: L-proline / N,N-dimethyl-formamide / 22 h / 100 - 120 °C

3: boron tribromide / dichloromethane / 16 h / 20 °C

With silver(II) sulfate; bromine; boron tribromide; L-proline; In dichloromethane; acetic acid; N,N-dimethyl-formamide;