N,N'-bis-(3-benzyloxy-2-hydroxy-1-phenyl-propyl)-2,2-dimethyl-malonamide

Base Information

Chemical Name:N,N'-bis-(3-benzyloxy-2-hydroxy-1-phenyl-propyl)-2,2-dimethyl-malonamide
CAS No.:496783-78-9
Molecular Formula:C₃₇H₄₂N₂O₆
Molecular Weight:610.75
Hs Code.:

<i>N</i>,<i>N</i>'-bis-(3-benzyloxy-2-hydroxy-1-phenyl-propyl)-2,2-dimethyl-malonamide

Synonyms:N,N'-bis-(3-benzyloxy-2-hydroxy-1-phenyl-propyl)-2,2-dimethyl-malonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N'-bis-(3-benzyloxy-2-hydroxy-1-phenyl-propyl)-2,2-dimethyl-malonamide

Chemical Property:

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Technology Process of N,N'-bis-(3-benzyloxy-2-hydroxy-1-phenyl-propyl)-2,2-dimethyl-malonamide

There total 1 articles about N,N'-bis-(3-benzyloxy-2-hydroxy-1-phenyl-propyl)-2,2-dimethyl-malonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5659-93-8
2,2-Dimethylmalonyl chloride

: 250605-24-4
(1R,2R)-1-amino-1-phenyl-3-(phenylmethoxy)propan-2-ol

: 496783-78-9
N,N'-bis-(3-benzyloxy-2-hydroxy-1-phenyl-propyl)-2,2-dimethyl-malonamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1002/1521-3765(20020916)8:18<4164::AID-CHEM4164>3.0.CO;2-G

Reference yield:

: 124-63-0
methanesulfonyl chloride

: 496783-78-9
N,N'-bis-(3-benzyloxy-2-hydroxy-1-phenyl-propyl)-2,2-dimethyl-malonamide

: Methanesulfonic acid (1R,2R)-2-[2-((1R,2R)-3-benzyloxy-2-methanesulfonyloxy-1-phenyl-propylcarbamoyl)-2-methyl-propionylamino]-1-benzyloxymethyl-2-phenyl-ethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1002/1521-3765(20020916)8:18<4164::AID-CHEM4164>3.0.CO;2-G

Reference yield:

: 496783-78-9
N,N'-bis-(3-benzyloxy-2-hydroxy-1-phenyl-propyl)-2,2-dimethyl-malonamide

: C₃₇H₃₈N₂O₄

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 2 h / 20 °C

2: KOH / methanol / 15 h / 20 °C

With potassium hydroxide; triethylamine; In methanol; dichloromethane;
DOI:10.1002/1521-3765(20020916)8:18<4164::AID-CHEM4164>3.0.CO;2-G