(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-methyl-3-(2,6,6-trimethyl-cyclohex-2-enyl)-propyl ester

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Chemical Name:(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-methyl-3-(2,6,6-trimethyl-cyclohex-2-enyl)-propyl ester
CAS No.:347852-08-8
Molecular Formula:C₂₃H₃₁F₃O₃
Molecular Weight:412.493
Hs Code.:

Synonyms:(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-methyl-3-(2,6,6-trimethyl-cyclohex-2-enyl)-propyl ester

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Chemical Property of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-methyl-3-(2,6,6-trimethyl-cyclohex-2-enyl)-propyl ester

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Technology Process of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-methyl-3-(2,6,6-trimethyl-cyclohex-2-enyl)-propyl ester

There total 4 articles about (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-methyl-3-(2,6,6-trimethyl-cyclohex-2-enyl)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 20445-33-4
(+)-α-methoxy-α-(trifluoromethyl)phenylacetyl chloride

: 347852-13-5
7,8-dihydro-α-ionol

: 347852-08-8
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-methyl-3-(2,6,6-trimethyl-cyclohex-2-enyl)-propyl ester

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/S0031-9422(00)00361-7

Reference yield:

: 7,8-dihydro-α-ionol

: 347852-08-8
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-methyl-3-(2,6,6-trimethyl-cyclohex-2-enyl)-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 mg / Hg(CN)2; 4 Angstroem molecular sieves / acetonitrile / 36 h / 20 °C

2: 90 percent / NH₃ / methanol / 24 h / 20 °C

3: 55 percent / β-glucosidase from sweet almond / acetate buffer / 16 h / 38 °C / pH 4.4

4: 30 percent / pyridine / CH₂Cl₂ / 12 h / 20 °C

With pyridine; β-glucosidase from sweet almond; 4 A molecular sieve; ammonia; mercury(II) cyanide; In methanol; dichloromethane; acetate buffer; acetonitrile; 1: Koenigs-Knorr reaction;
DOI:10.1016/S0031-9422(00)00361-7

Reference yield:

: 347852-06-6
(2R,3S,4S,5R,6R)-2-Hydroxymethyl-6-[(R)-1-methyl-3-(2,6,6-trimethyl-cyclohex-2-enyl)-propoxy]-tetrahydro-pyran-3,4,5-triol

: 347852-08-8
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-methyl-3-(2,6,6-trimethyl-cyclohex-2-enyl)-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / β-glucosidase from sweet almond / acetate buffer / 16 h / 38 °C / pH 4.4

2: 30 percent / pyridine / CH₂Cl₂ / 12 h / 20 °C

With pyridine; β-glucosidase from sweet almond; In dichloromethane; acetate buffer;
DOI:10.1016/S0031-9422(00)00361-7