2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O²,O⁶-bis-[2-(4-nitrophenyl)ethyl]xanthosine

Base Information

• Chemical Name: 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O²,O⁶-bis-[2-(4-nitrophenyl)ethyl]xanthosine
• CAS No.: 292050-45-4
• Molecular Formula: C₄₇H₄₄N₆O₁₁
• Molecular Weight: 868.9

Synonyms:2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O²,O⁶-bis-[2-(4-nitrophenyl)ethyl]xanthosine

Chemical Property of 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O²,O⁶-bis-[2-(4-nitrophenyl)ethyl]xanthosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O²,O⁶-bis-[2-(4-nitrophenyl)ethyl]xanthosine

There total 5 articles about 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O²,O⁶-bis-[2-(4-nitrophenyl)ethyl]xanthosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) + 2'-deoxy-O2,O6-bis-[2-(4-nitrophenyl)ethyl]xanthosine (123107-74-4) → 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O2,O6-bis-[2-(4-nitrophenyl)ethyl]xanthosine (292050-45-4)

Guidance literature:

In pyridine; for 22h;

DOI:10.1002/1522-2675(20000705)83:7<1517::AID-HLCA1517>3.0.CO;2-S

Reference yield:

2-(4-nitrophenyl)ethyl iodide (20264-96-4) → 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O2,O6-bis-[2-(4-nitrophenyl)ethyl]xanthosine (292050-45-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Ag₂CO₃ / benzene / 1 h / Heating

1.2: 93 percent / benzene / 15 h / 50 °C

2.1: NH₃ / methanol; H₂O / 24 h / 20 °C

3.1: 5.26 g / pyridine / 22 h

With ammonia; silver carbonate; In pyridine; methanol; water; benzene; 1.1: Reduction / 1.2: Substitution / 2.1: Deacetylation / 3.1: Condensation;

DOI:10.1002/1522-2675(20000705)83:7<1517::AID-HLCA1517>3.0.CO;2-S

Reference yield:

2-amino-6-(2-(p-nitrophenyl)ethyloxy)-9-[2'-deoxy-β-D-erythropentofuranosyl]purine diacetate (108310-92-5) → 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O2,O6-bis-[2-(4-nitrophenyl)ethyl]xanthosine (292050-45-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 57 percent / NaNO₂; AcOH

2.1: Ag₂CO₃ / benzene / 1 h / Heating

2.2: 93 percent / benzene / 15 h / 50 °C

3.1: NH₃ / methanol; H₂O / 24 h / 20 °C

4.1: 5.26 g / pyridine / 22 h

With ammonia; acetic acid; silver carbonate; sodium nitrite; In pyridine; methanol; water; benzene; 1.1: Oxidation / 2.1: Reduction / 2.2: Substitution / 3.1: Deacetylation / 4.1: Condensation;

DOI:10.1002/1522-2675(20000705)83:7<1517::AID-HLCA1517>3.0.CO;2-S

upstream raw materials:

4,4'-dimethoxytrityl chloride

2'-deoxy-O²,O⁶-bis-[2-(4-nitrophenyl)ethyl]xanthosine

2-(4-nitrophenyl)ethyl iodide

2-amino-6-(2-(p-nitrophenyl)ethyloxy)-9-[2'-deoxy-β-D-erythropentofuranosyl]purine diacetate

Downstream raw materials:

2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O²,O⁶-bis-[2-(4-nitrophenyl)ethyl]xanthosine 3'-(2-cyanoethyl diisopropylphosphoramidite)

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