20264-96-4

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-Iodo-ethyl)-4-nitro-benzene is used as a synthetic intermediate for the production of pharmaceuticals, playing a vital role in the development of new medicines. Its unique chemical structure allows for the creation of a diverse range of drug molecules, contributing to advancements in healthcare.
Used in Dye and Pigment Production:
In the dye and pigment industry, 1-(2-Iodo-ethyl)-4-nitro-benzene is employed as a key component in the synthesis of various dyes and pigments. Its chemical properties enable the production of vibrant and stable colorants used in textiles, plastics, and other applications.

Upstream product

• 20264-95-3 2-(4-nitrophenyl)ethyl chloride 
• 5339-26-4 (4-nitrophenyl)ethyl bromide 
• 20020-28-4 <(p-Nitrophenyl)ethyl>-β-sulfonic ester 
• 622-24-2 2-phenylethyl chloride 
• 104-03-0 4-nitrobenzeneacetic acid 
• 100-27-6 2-(4-nitrophenyl)ethanol 
• 288-32-4 1H-imidazole 
• 6531-13-1 1-[4-nitrophenyl]-1-ethanol 

Downstream Products

• 134529-13-8 1'-(2-(4-nitrophenyl)ethyl)-2,3'-bipyridinium iodide 
• 87875-18-1 Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxy]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 
• 107463-71-8 1,3,6-Trimethyl-7-(<2-(p-nitrophenyl)ethyl>thio)pteridin-2,4(1H,3H)-dion 
• 102562-11-8 2',3',5'-tri-O-acetyl-8-bromo-O²,O⁶-bis<2-(p-nitrophenyl)ethyl>xanthosine 
• 87875-17-0 2',3'-di-O-benzoyl-5'-O-monomethoxytrityl-O⁴-p-nitrophenylethyluridine 
• 102562-13-0 2',3',5'-tri-O-acetyl-2,6,8-tris<2-(p-nitrophenyl)ethoxy>-9-(β-D-ribofuranosyl)-9H-purine 
• 100-13-0 4-nitrostyrene 
• 87875-13-6 3',5'-di-O-acetyl-O⁴-p-nitrophenylethylthymidine 
• 6291-54-9 (4-nitro-phenethyl)-malonic acid dimethyl ester 
• 87875-14-7 3'-O-benzoyl-5'-O-monomethoxytrityl-O⁴-p-nitrophenylethylthymidine 
• 173169-02-3 2',3',5'-tri-O-acetyl-O²,O⁴-bis<2-(4-nitrophenyl)ethyl>pseudouridine 
• 173169-04-5 2',3',5'-tri-O-benzoyl-S⁴-<2-(4-nitrophenyl)ethyl>-4-thiouridine 
• 116980-91-7 2',3',5'-tri-O-acetyl-O⁴-<2-(4-nitrophenyl)ethyl>uridine 
• 292050-44-3 3',5'-di-O-acetyl-2'-deoxy-O²,O⁶-bis-[2-(4-nitrophenyl)ethyl]xanthosine 

Relevant academic research and scientific papers

N-Methylation and N-oxidation of the less reactive nitrogen atom of a 2,3'-bipyridine. Two general methods for polyazines

5-Carbamoyl-2,3'-bipyridine model compound was N-methylated or N-oxidized at the less reactive 2-pyridyl ring for the first time. Two different schemes were developed.

One-Pot Deoxygenation and Substitution of Alcohols Mediated by Sulfuryl Fluoride

Sulfuryl fluoride is a valuable reagent for the one-pot activation and derivatization of aliphatic alcohols, but the highly reactive alkyl fluorosulfate intermediates limit both the types of reactions that can be accessed as well as the scope. Herein, we report the SO2F2-mediated alcohol substitution and deoxygenation method that relies on the conversion of fluorosulfates to alkyl halide intermediates. This strategy allows the expansion of SO2F2-mediated one-pot processes to include radical reactions, where the alkyl halides can also be exploited in the one-pot deoxygenation of primary alcohols under mild conditions (52-95% yield). This strategy can also enhance the scope of substitutions to nucleophiles that are previously incompatible with one-pot SO2F2-mediated alcohol activation and enables substitution of primary and secondary alcohols in 54-95% yield. Chiral secondary alcohols undergo a highly stereospecific (90-98% ee) double nucleophilic displacement with an overall retention of configuration.

Indium(III)-catalyzed reductive bromination and iodination of carboxylic acids to alkyl bromides and iodides: Scope, mechanism, and one-pot transformation to alkyl halides and amine derivatives

Highly effective indium(III)-catalyzed reductive bromination or iodination of a variety of carboxylic acids with 1,1,3,3-tetramethyldisiloxane (TMDS) and a source of bromine or iodine is described. This functional group interconversion has high tolerance for several functional groups, such as halogens, a hydroxy group, a nitro group, an olefin part, and a sulfide moiety. This indium catalytic system is also applicable to the reductive iodination of aldehyded, acyl chlorides, and esters. Furthermore, this reducing system can be applied to the one-pot synthesis of alkyl halides and amine derivatives via the addition of nucleophiles. Insight into the reaction mechanism was gained via the time course of 1H and 13C NMR monitoring experiments and the corresponding stepwise reactions.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir 1.1) channel. The compounds act as diuretics and natriuretics and are valuable pharmaceutically active compounds for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension and conditions resulting from excessive salt and water retention.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula I I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds act as diuretics and natriuretics and are valuable pharmaceutically active compounds for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension and conditions resulting from excessive salt and water retention.

Non-standard nucleoside analogs with reduced epimerization

This invention relates to nucleoside, nucleotide, and oligonucleotide analogs that incorporate non-standard nucleobase analogs, defined to be those that present a pattern of hydrogen bonds to a paired nucleobase analog in a complementary strand that is different from the pattern presented by adenine, guanine, cytosine, and thymine. The invention is specifically concerned with compositions of matter that present the donor-donor-acceptor, donor-acceptor-donor, and acceptor-donor-donor non-standard hydrogen bonding patterns on pyrimidine analogs, where nucleoside analogs bearing these pyrimidine analogs do not epimerize as easily as those known in the art. The heterocycles on these nucleoside analogs are diaminopyridines and aminopyridones that have electron withdrawing groups attached to the position analogous to the 5-position of the ring in standard pyrimidines, including nitro, cyano, and carboxylic acid derivatives.

Synthesis of tetrahydronaphthalene lignan esters by intramolecular cyclization of ethyl p-azidophenyl-2-phenylalkanoates and evaluation of the growth inhibition of human tumor cell lines

Figure Presented. Intramolecular cyclization via nitrenium ion of 2-phenylpentanoic/2-phenylbutanoic acid esters with a terminal p-azidophenyl group gives direct access to tetrahydronaphthalene lignan esters. The p-azidophenyl-substituted butanoate led to

Selective conversion of alcohols into alkyl iodides using a thioiminium salt

(Chemical Equation Presented) Treatment of a range of primary and secondary alcohols with MeSCH=NMe2+ I- affords the corresponding alkyl iodides in excellent yield with straightforward purification. Selective formation of a primary iodide in the presence of a secondary alcohol can be achieved.

Thiazolidinones, their production and use as pharmaceutical agents

Thiazolidinones of general formula I in which Q, A, B, X, R1 and R2 have the meanings that are indicated in the description, as well as those of general formula IA in which Q, A, B, X, R1 and R2a have the meanings that are indicated in the description, their production and use as inhibitors of the polo-like kinase (PLK) for treating various diseases as well as intermediate products for the production of thiazolidinones are described.