N-(N-Benzyloxycarbonyl-L-γ-glutamyl-1-tert.-butylester)-glycin-tert.-butylester

Base Information

• Chemical Name: N-(N-Benzyloxycarbonyl-L-γ-glutamyl-1-tert.-butylester)-glycin-tert.-butylester
• CAS No.: 103673-94-5
• Molecular Formula: C₂₃H₃₄N₂O₇
• Molecular Weight: 450.532
• Mol file: 103673-94-5.mol

Synonyms:N-(N-Benzyloxycarbonyl-L-γ-glutamyl-1-tert.-butylester)-glycin-tert.-butylester

Chemical Property of N-(N-Benzyloxycarbonyl-L-γ-glutamyl-1-tert.-butylester)-glycin-tert.-butylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(N-Benzyloxycarbonyl-L-γ-glutamyl-1-tert.-butylester)-glycin-tert.-butylester

There total 3 articles about N-(N-Benzyloxycarbonyl-L-γ-glutamyl-1-tert.-butylester)-glycin-tert.-butylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic acid tert-butyl ester (540-88-5) → N-(N-Benzyloxycarbonyl-L-γ-glutamyl-1-tert.-butylester)-glycin-tert.-butylester (103673-94-5)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) HClO₄, (ii) aq. NaOH, acetone

2: (i) 1-ethyl-piperidine, ClCO₂Et, toluene, (ii) /BRN= 2039000/

Reference yield:

(S)-2-Benzyloxycarbonylamino-pentanedioic acid 5-methyl ester (4652-65-7) → N-(N-Benzyloxycarbonyl-L-γ-glutamyl-1-tert.-butylester)-glycin-tert.-butylester (103673-94-5)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) HClO₄, (ii) aq. NaOH, acetone

2: (i) 1-ethyl-piperidine, ClCO₂Et, toluene, (ii) /BRN= 2039000/

Reference yield:

Glycine tert-butyl ester (6456-74-2) + (S)-2-(benzyloxycarbonylamino)pentanedioic acid tert-butyl ester (5891-45-2) → N-(N-Benzyloxycarbonyl-L-γ-glutamyl-1-tert.-butylester)-glycin-tert.-butylester (103673-94-5)

Guidance literature:

Multistep reaction; (i) 1-ethyl-piperidine, ClCO₂Et, toluene, (ii) /BRN= 2039000/;

upstream raw materials:

Glycine tert-butyl ester

(S)-2-(benzyloxycarbonylamino)pentanedioic acid tert-butyl ester

acetic acid tert-butyl ester

(S)-2-Benzyloxycarbonylamino-pentanedioic acid 5-methyl ester

Downstream raw materials:

(S)-4-(tert-Butoxycarbonylmethyl-carbamoyl)-2-{4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyric acid tert-butyl ester