8a-methoxycarbonylmethyl-3-(S)-phenylhexahydrooxazolo[3,2-a]pyridine

Base Information

Chemical Name:8a-methoxycarbonylmethyl-3-(S)-phenylhexahydrooxazolo[3,2-a]pyridine
CAS No.:457603-49-5
Molecular Formula:C₁₆H₂₁NO₃
Molecular Weight:275.348
Hs Code.:

Synonyms:8a-methoxycarbonylmethyl-3-(S)-phenylhexahydrooxazolo[3,2-a]pyridine

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Chemical Property of 8a-methoxycarbonylmethyl-3-(S)-phenylhexahydrooxazolo[3,2-a]pyridine

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Technology Process of 8a-methoxycarbonylmethyl-3-(S)-phenylhexahydrooxazolo[3,2-a]pyridine

There total 6 articles about 8a-methoxycarbonylmethyl-3-(S)-phenylhexahydrooxazolo[3,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 20989-17-7
(2S)-2-phenylglycinol

: 121823-95-8
methyl 7-iodohept-2-ynoate

: 457603-49-5
8a-methoxycarbonylmethyl-3-(S)-phenylhexahydrooxazolo[3,2-a]pyridine

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium carbonate; In acetonitrile; Heating;
DOI:10.1016/S0040-4039(02)00577-4

Reference yield: 67.0%

: 607388-44-3
{2-[4-((S)-2-hydroxy-1-phenylethylamino)butyl]-[1,3]dioxolan-2-yl}acetic acid methyl ester

: 457603-49-5
8a-methoxycarbonylmethyl-3-(S)-phenylhexahydrooxazolo[3,2-a]pyridine

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃;
DOI:10.1016/S0040-4020(03)00980-3

Reference yield:

: 22977-45-3
methyl 7-chloro-3-oxoheptanoate

: 457603-49-5
8a-methoxycarbonylmethyl-3-(S)-phenylhexahydrooxazolo[3,2-a]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / HC(OMe)3; p-TSA / 6 h / 20 °C

2: NaI; Na₂CO₃; tetrabutylammonium iodide / acetonitrile / Heating

3: 67 percent / BF₃*Et₂O / CH₂Cl₂ / 0 °C

With boron trifluoride diethyl etherate; tetra-(n-butyl)ammonium iodide; sodium carbonate; toluene-4-sulfonic acid; sodium iodide; trimethyl orthoformate; In dichloromethane; acetonitrile;
DOI:10.1016/S0040-4020(03)00980-3